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ABSTRACT:
The scope of the present study is focused to explore the antimicrobial properties of thermally stable poly (NVCco-MOEMA). Copolymers of N-Vinyl Carbazole (NVC) with Methoxy ethylmethacrylate (MOEMA) at different feed compositions were prepared by free radical solution polymerization at (60 ± 5)°C using benzoyl peroxide (BPO) as an initiator. The characterization of the copolymers was carried out by FTIR and JH-NMR spectroscopy. The high thermal stability and higher Tg values of the copolymers were predicted by Thermo gravimetric analysis (TGA) and Differential scanning calorimetry (DSC). Antimicrobial activities of the copolymers were also investigated against the selected pathogenic bacteria's (Staphylococcus aureus, Escherichi coli, Bacillus subtilis, Salmonella Paratyphi) and fungi's (Candida albicans, Aspergillus niger). Microbial screening of both the Homopolymer and Copolymers were carried out and their activities studied. The antimicrobial activity of the Copolymers was higher than that of the Homopolymer. This shows that copolymerization with methoxy ethylmethacrylate moiety plays a very important role in the antimicrobial activity.
KEYWORDS: NVC-co-MOEMA; Copolymer; Thermo gravimetric analysis; Antimicrobial activity; Microbial screening.
INTRODUCTION:
In the 1990s, antimicrobial polymer systems were surveyed by Worley and Sun and Afinogenov and Panarin. 1 2 Varieties of antimicrobial polymers have been considered in several comprehensive reviews during the past decade. Synthesis of antimicrobial polymers such as polyionenes (polymers with positively charged nitrogen atoms located in the backbone of a macro chain) was carried out. Copolymerization techniques have a number of advantages in controlling the degree of functional groups in the product, controlling its structure, and introducing the required properties into the polymer system.
Pleurdean and co-workers reported the synthesis of acrylic esters that are useful as biocides, by reacting pentachlorophenol, p-chloro-m-cresol and o-phenyl phenol with acryloyl chloride3. Oh and co-workers synthesized 2,4,4' -trichloro-2' -acryloyloxydiphenyl ether and its homo- and copolymers with methyl methacrylate (MMA), styrene and 2-hydroxyethyl methacrylate and tested bactericidal properties against Staphylococcus aureus and Pseudomonas aeruginosa microorganisms.4,5 Thus, growth inhibition of these bacteria by the copolymers N-vinyl carbazole (NVC) with ethyl methacrylates (EMA) has been studied. In the present investigation, N-Vinyl carbazole (NVC) was copolymerized with Methoxy ethylmethacrylate (MOEMA) which may be useful in pharmaceuticals, pesticides, paints, coatings, inks, adhesives and cosmetics.6 This article discusses the synthesis and characterization of the copolymers using different feed ratios. FTIR and 1H-NMR spectroscopy...