Abstract

Estimates of the prevalence of Parkinson’s disease in North America have varied widely and many estimates are based on small numbers of cases and from small regional subpopulations. We sought to estimate the prevalence of Parkinson’s disease in North America by combining data from a multi-study sampling strategy in diverse geographic regions and/or data sources. Five separate cohort studies in California (2), Minnesota (1), Hawaii USA (1), and Ontario, Canada (1) estimated the prevalence of PD from health-care records (3), active ascertainment through facilities, large group, and neurology practices (1), and longitudinal follow-up of a population cohort (1). US Medicare program data provided complementary estimates for the corresponding regions. Using our age- and sex-specific meta-estimates from California, Minnesota, and Ontario and the US population structure from 2010, we estimate the overall prevalence of PD among those aged ≥45 years to be 572 per 100,000 (95% confidence interval 537–614) that there were 680,000 individuals in the US aged ≥45 years with PD in 2010 and that that number will rise to approximately 930,000 in 2020 and 1,238,000 in 2030 based on the US Census Bureau population projections. Regional variations in prevalence were also observed in both the project results and the Medicare-based calculations with which they were compared. The estimates generated by the Hawaiian study were lower across age categories. These estimates can guide health-care planning but should be considered minimum estimates. Some heterogeneity exists that remains to be understood.

Details

Title
Prevalence of Parkinson’s disease across North America
Author
Marras, C 1 ; Beck, J C 2   VIAFID ORCID Logo  ; Bower, J H 3 ; Roberts, E 4 ; Ritz, B 5 ; Ross, G W 6 ; Abbott, R D 7 ; Savica, R 3 ; S K Van Den Eeden 8 ; Willis, A W 9 ; Tanner, C M 10 

1  The Morton and Gloria Shulman Movement Disorders Centre and the Edmond J Safra Program in Parkinson’s Research, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada 
2  The Parkinson’s Foundation, New York, NY, USA; New York University, New York, NY, USA 
3  Department of Neurology, School of Medicine, Mayo Clinic, Rochester, MN, USA 
4  Public Health Institute, Oakland, CA, USA 
5  Department of Epidemiology, UCLA Fielding School of Public Health and UCLA Geffen School of Medicine, Los Angeles, CA, USA; Department of Environmental Health, UCLA Fielding School of Public Health and UCLA Geffen School of Medicine, Los Angeles, CA, USA; Department of Neurology, UCLA Fielding School of Public Health and UCLA Geffen School of Medicine, Los Angeles, CA, USA 
6  Veterans Affairs Pacific Islands Health Care System, Honolulu, HI, USA 
7  Center for Epidemiologic Research in Asia, Shiga University of Medical Science, Otsu, Japan 
8  Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA 
9  Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA; Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA 
10  Department of Neurology, University of California – San Francisco & PD Research Education and Clinical Center, San Francisco Veterans Affairs Health Care System, San Francisco, CA, USA 
Pages
1-7
Publication year
2018
Publication date
Jul 2018
Publisher
Nature Publishing Group
e-ISSN
23738057
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41531-018-0058-0
ProQuest document ID
2068329555
Copyright
© 2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.