Abstract

An International Bone Marrow Transplant Registry survey confirmed that most centres considered patients to have steroid-refractory GVHD after 5 d of treatment [10]. [...]we defined steroid-refractory GVHD as requiring continuous administration of steroids for 5 d or exhibiting worsening of symptoms within 3 d, or by a haematologist’s determination of whether steroid-refractory GVHD was present. In the present study, 75% (15/20) of patients in the pathological GVHD-positive group and 54% (17/31) of patients in the negative group had various colonoscopic findings, and there was no statistically significant difference between the two groups. [...]if colonoscopic examination is limited to the rectum, it is impossible to diagnose GVHD, the severity of GVHD, and steroid-refractory GVHD. [...]we observed villous atrophy in 14 (70%) of 20 patients pathologically diagnosed with acute GVHD. [...]we found that villous atrophy in the terminal ileum is a relatively common finding in these patients and may be effective in diagnosing patients with acute GVHD. [...]because the data were collected retrospectively, the biopsy location and the number of samples were different depending on the operator performing ileocolonoscopy.

Details

Title
Villous atrophy in the terminal ileum is a specific endoscopic finding correlated with histological evidence and poor prognosis in acute graft-versus-host disease after allo-hematopoietic stem cell transplantation
Author
Sugihara, Yuusaku; Hiraoka, Sakiko; Fujii, Nobuharu; Takashima, Shiho; Yamasaki, Yasushi; Inokuchi, Toshihiro; Takahara, Masahiro; Kuwaki, Kenji; Harada, Keita; Tanaka, Takehiro; Okada, Hiroyuki
Publication year
2018
Publication date
2018
Publisher
BioMed Central
e-ISSN
1471230X
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2071690600
Copyright
Copyright © 2018. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and conditions, you may use this content in accordance with the terms of the License.