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Abstract
Because of the conserved residues in N-terminal RRMs of MSI1 and MSI2 [43], the same Numb RNA in our MSI1 FP assay also binds to MSI2-FL and MSI2-RRM1 (data not shown). [...]more DiR existed in the liver of free DiR group. Since liver is the main organ for Gn metabolism, this result indicates that the drug in liposomes may have a long-term effect as compared with the free drug. In colorectal cancer initiation and maintenance, a recent study demonstrated the functional redundancy between MSI1 and MSI2 [78]. [...]using a MSI1/MSI2 dual inhibitor such as Gn in patients with MSI overexpression suggests an improved therapeutic outcome. [...]the Gn-lip exhibited a significant tumor inhibition efficacy and a low systemic toxicity in the mice.
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