Abstract

Mutations in the isocitrate dehydrogenase (IDH mut) gene have gained paramount importance for the prognosis of glioma patients. To date, reliable techniques for a preoperative evaluation of IDH genotype remain scarce. Therefore, we investigated the potential of O-(2-[18F]fluoroethyl)-L-tyrosine (FET) PET radiomics using textural features combined with static and dynamic parameters of FET uptake for noninvasive prediction of IDH genotype. Prior to surgery, 84 patients with newly diagnosed and untreated gliomas underwent FET PET using a standard scanner (15 of 56 patients with IDH mut) or a dedicated high-resolution hybrid PET/MR scanner (11 of 28 patients with IDH mut). Static, dynamic and textural parameters of FET uptake in the tumor area were evaluated. Diagnostic accuracy of the parameters was evaluated using the neuropathological result as reference. Additionally, FET PET and textural parameters were combined to further increase the diagnostic accuracy. The resulting models were validated using cross-validation. Independent of scanner type, the combination of standard PET parameters with textural features increased significantly diagnostic accuracy. The highest diagnostic accuracy of 93% for prediction of IDH genotype was achieved with the hybrid PET/MR scanner. Our findings suggest that the combination of conventional FET PET parameters with textural features provides important diagnostic information for the non-invasive prediction of the IDH genotype.

Details

Title
Predicting IDH genotype in gliomas using FET PET radiomics
Author
Lohmann, Philipp 1   VIAFID ORCID Logo  ; Lerche, Christoph 2 ; Bauer, Elena K 3 ; Steger, Jan 3 ; Stoffels, Gabriele 2 ; Blau, Tobias 4 ; Dunkl, Veronika 3 ; Kocher, Martin 1 ; Viswanathan, Shivakumar 2   VIAFID ORCID Logo  ; Filss, Christian P 2 ; Stegmayr, Carina 2 ; Ruge, Maximillian I 5 ; Neumaier, Bernd 2   VIAFID ORCID Logo  ; Shah, Nadim J 6 ; Fink, Gereon R 7 ; Langen, Karl-Josef 8 ; Galldiks, Norbert 9 

1  Inst. of Neuroscience and Medicine (INM-3, −4, −5), Forschungszentrum Juelich, Juelich, Germany; Dept. of Stereotaxy and Functional Neurosurgery, University of Cologne, Cologne, Germany 
2  Inst. of Neuroscience and Medicine (INM-3, −4, −5), Forschungszentrum Juelich, Juelich, Germany 
3  Dept. of Neurology, University of Cologne, Cologne, Germany 
4  Dept. of Neuropathology, University of Cologne, Cologne, Germany 
5  Dept. of Stereotaxy and Functional Neurosurgery, University of Cologne, Cologne, Germany 
6  Inst. of Neuroscience and Medicine (INM-3, −4, −5), Forschungszentrum Juelich, Juelich, Germany; Dept. of Neurology, University Hospital RWTH Aachen, Aachen, Germany 
7  Inst. of Neuroscience and Medicine (INM-3, −4, −5), Forschungszentrum Juelich, Juelich, Germany; Dept. of Neurology, University of Cologne, Cologne, Germany 
8  Inst. of Neuroscience and Medicine (INM-3, −4, −5), Forschungszentrum Juelich, Juelich, Germany; Dept. of Nuclear Medicine, University Hospital RWTH Aachen, Aachen, Germany 
9  Inst. of Neuroscience and Medicine (INM-3, −4, −5), Forschungszentrum Juelich, Juelich, Germany; Dept. of Neurology, University of Cologne, Cologne, Germany; Center of Integrated Oncology (CIO), Universities of Cologne and Bonn, Cologne, Germany 
Pages
1-9
Publication year
2018
Publication date
Sep 2018
Publisher
Nature Publishing Group
e-ISSN
20452322
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41598-018-31806-7
ProQuest document ID
2100357283
Copyright
© 2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.