Abstract

10 ng/mL was used to rule out GHD. Diagnostic accuracy of not only single time points but also time points in pairs was calculated. Statistical Analysis: The data were analyzed using SPSS statistical software 22.0. Descriptive statistics were used for analyzing demographic data. Mode for time to peak GH was calculated in each group. The specificity and false positive rates at each time point as well as combined time points were determined. Results: Assaying a single sample at 60 min after clonidine resulted in 20.5% false positive tests with specificity of 79.5%. Addition of the 90 min sample increased specificity to 92.3%. Conclusion: The 60 min sample after clonidine stimulation was the best single sample to rule out GH deficiency. Combined sampling at 60 min + 90 min is economical and less cumbersome, with minimal compromise on the specificity.

Details

Title
Clonidine stimulation test: Is single best time point, convenient yet efficacious?
Author
Thakur, Darshana 1 ; Bhagwat, Nikhil 1 ; Bhide, Milind 2 ; Yerawar, Chaitanya 1 ; Ghanekar, Gayatri 1 ; Sonawane, Ashutosh 1 ; Chadha, Manoj 1 ; Varthakavi, Premlata 1 

 Department of Endocrinology, Bai Yamunabai Laxman (BYL) Nair Charitable Hospital and Topiwala National Medical College, A.L. Nair Road, Mumbai Central, Mumbai, Maharashtra 
 Bhide Laboratory Services, Girgaon, Mumbai, Maharashtra 
Pages
511-514
Publication year
2018
Publication date
Jul/Aug 2018
Publisher
Medknow Publications & Media Pvt. Ltd.
ISSN
22308210
e-ISSN
22309500
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2112130617
Copyright
© 2018. This work is published under https://creativecommons.org/licenses/by-nc-sa/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.