Protective Effect of Sodium Tetraborate on Chromium-induced Brain Damage in Rats

Abstract

Hexavalent chromium presents a particular threat due to its high toxicity. In this study showed the neuroprotective effect of sodium tetraborate in chromic intoxication. The experiment was performed on Wistar rats divided into 4 groups: 1 group - control; 2 group - single intraperitoneal injection of K ₂ Сr ₂ O ₇ in a dose of 0,5LD ₅₀ , in the 3 and 4 groups with drinking water received Na ₂ B ₄ O ₇ . Animals of the 3 group - 4 mg/kg of body weight, in 4 group - 72 mg/kg of body weight daily for 10 days, the last administration of Na ₂ B ₄ O ₇ was combined with a single intraperitoneal injection of K ₂ Сr ₂ O ₇ at a dose of 14 mg/kg (0,5LD ₅₀ ). Na ₂ B ₄ O ₇ in a dose of 4 mg/kg leads to a decrease in the level of MDA by 33%, an increase in the activity of catalase by 69%, superoxide dismutase by 21%, GR by 49%. Na ₂ B ₄ O ₇ at a dose of 72 mg/kg increases the MDA content by 31% in comparison with the data of rats of chromic intoxication. K ₂ Сr ₂ O ₇ reduces the GSH level by 42%, the non-protein thiol by 36%. Na ₂ B ₄ O ₇ at a dose of 4 mg/kg increased the GSH level by 53%, the non-protein thiol by 35%, and at a dose of 72 mg/kg reduced the GSH content by 23% (ρ <0.05), the non-protein thiol by 20% (ρ<0.05) in comparison with the data of rats exposed to k ₂ сr ₂ o ₇ .