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Background: Encouraging results indicate that stem cells derived EVs could benefit tissue repair, thereby representing a promising alternative for stem cells. Nonetheless, preclinical studies of EVs therapy have yielded inconsistent results. Therefore, we conducted a systemic review and meta-analysis in order to establish the overall effects of stem cells derived EVs in preclinical studies and explore the factors may cause the controversy.
Methods: PubMed, Embase, Web of Science and the Cochrane library were systematically searched for studies from inception to October 2017...