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ABSTRACT
Sertraline is a selective serotonin reuptake inhibitor (SSRI) with antidepressant and anxiolytic properties. Hematological adverse effects related to sertraline are rare. Drug-induced neutropenia is a rare but fatal condition. Patients may present with non-specific symptoms like fever, shivering, sore throat, or muscle and joint pain. Even though the condition is hard to diagnose, an early detection is essential. In this article, we present a male patient with neutropenia related to sertraline treatment.
Keywords: Antidepressant, neutropenia, obsessive compulsive disorder, sertraline
ÖZ
Sertralin, antidepresan ve anksiyolitik özellikleri olan seçici serotonin gerialim inhibitörü (SSGI) grubundan bir antidepresandir. Sertraline bagli hematolojik yan etkiler nadirdir. Ilaca bagli nötropeni gelisimi nadir ancak ölümcül bir tablodur. Hastalar ates, titreme, bogaz agrisi, kas ve eklem agrisi gibi nonspesifik semptomlarla basvurabilir. Tani koymak zor olsa da zamaninda taninmasi çok önemlidir. Bu yazida sertralin kullanimi sonucu nötropeni gelisen erkek hasta sunulmustur.
Anahtar kelimeler: Antidepresan, nötropeni, obsesif kompulsif bozukluk, sertralin
INTRODUCTION
Sertraline is an serotonine reuptake inhibitor (SSRI) antidepressant with antidepressant and anxiolytic properties. It is indicated in the treatment of several psychiatric disorders such as major depressive disorder, obsessive-compulsive disorder (OCD), and posttraumatic stress disorder (1). Sertraline causes a highly selective and potent serotonin reuptake inhibition and has a minimal effect on the reuptake of noradrenaline and dopamine. Sertraline is a preferred antidepressant due to its low adverse effect profile. The most common adverse effects are nausea, headache, dry mouth, diarrhea, insomnia, and dizziness (2). Hematological adverse effects related to sertraline are rare.
In this article, we present a male patient with neutropenia related to sertraline treatment.
CASE
We report a 45-year-old male patient who had been under follow-up due to OCD for nine years. A complete blood count was performed by the department where the patient was admitted with complaints of a sore throat, muscle pain, and fatigue. As the white blood cell (WBC) was 1260/mm3 and neutrophil count was 150/mm3, the patient was referred to the outpatient department of psychiatry. The anamnesis revealed that the patient had been using sertraline (150mg/day) for eight months and he was in remission. According to his medical history, he had used antidepressants like fluvoxamine, paroxetine, and clomipramine and he had to discontinue these drugs because of adverse effects such as fatigue, constipation, and dry mouth...