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Introduction
Multiple organ dysfunction syndrome (MODS) refers to the simultaneous occurrence of two or more organ dysfunctions or failure. MODS is common in severely infected and severely traumatized patients, and is the most common complication of acute and critically ill patients (1,2). MODS is also a common cause of death in acute and critically ill patients, and mortality rate can be as high as 80%, if dysfunction or failure of three organs exist (3). It's very difficult to control the development of MODS, therefore, prevention, early detection and early treatment are the key for survival (4).
Myoglobin (Mb) is widely present in muscle tissue to transport and store oxygen. Mb level increases in cardiac function damage or failure, and renal failure. Heart and kidneys are two of the most common early-affected organs in MODS (5,6). N-terminal pro-brain natriuretic peptide (NT-proBNP) is a newly discovered biomarker in recent years. NT-proBNP has been widely used in the detection of heart failure due to its high specificity and sensitivity (7). Changes in the level of NT-proBNP have also been found in sepsis, renal failure and other diseases (8,9). Nuclear factor-κB (NF-κB) is a pleiotropic and inducible nuclear transcription factor regulated by inflammatory response and stress response. Organs or system damage can stimulate the release of inflammatory cytokines, activate NF-κB signaling system, and promote the release of NF-κB. NF-κB can also promote the release of proinflammatory cytokines to aggregate the organ or system injury (10,11).
Therefore, this study detected the expression of Mb, NT-proBNP and NF-κB in patients with MODS and explored the clinical significance with the expectation of providing reference for clinical prevention and treatment of MODS.
Patients and methods
Subjects
A total of 314 patients with severe disease were selected during their stays at the emergency ward of the Third People's Provincial Hospital of Henan Province (Zhengzhou, China) from July 2014 to December 2015. Among them, 70 patients with MODS were selected as MODS group, including 42 males and 28 females, with a mean age of 67.5±20.4 years. A total of 108 patients with single organ or system injury were selected as the key prevention group, including 63 males and 45 females, with a mean age of 59.4±19.8 years; and the remaining 136 patients without obvious organ...