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© 2018. This work is published under http://creativecommons.org/licenses/by-nc-sa/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Nitrogen containing heterocyclic compounds are biologically significant molecules. This is especially true for pyrrole a five membered nitrogen containing aromatic molecule, which is present as a key structural motif in a large number of drugs and lead molecules. This review aims to provide an overview of the multi-component reaction (MCR) based methodologies used for the synthesis of pyrrole and its derivatives, focusing particularly on eco-friendly methods that avoid the use of hazardous reagents, solvents and catalysts are deemed especially relevant to the disciplines of medicinal chemistry and drug discovery.

Details

Title
A Critical Review on Advances in the Multicomponent Synthesis of Pyrroles
Author
Iqbal Azad; Firoj Hassan; Saquib, Mohammad; Ahmad, Naseem; Abdul Rahman Khan; Al-Sehemi, Abdillah G; Malik Nasibullah
Pages
1670-1700
Publication year
2018
Publication date
2018
Publisher
Oriental Scientific Publishing Company
ISSN
0970020X
e-ISSN
22315039
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2127537259
Copyright
© 2018. This work is published under http://creativecommons.org/licenses/by-nc-sa/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.