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Basic Res Cardiol 103:385396 (2008) DOI 10.1007/s00395-008-0716-1
ORIGINAL CONTRIBUTION
Laurence Lucats Xavier Monnet Alain Biz Valrie Chetboul Jean-Louis Pouchelon Luc Hittinger Alain Berdeaux Bijan Ghaleh
Regional and temporal heterogeneity of postsystolic wall thickening is associated with left ventricular asynchrony in normal and experimental stunned myocardium
Received: 1 October 2007 Returned for 1. Revision: 23 October 20071. Revision received: 19 December 2007 Returned for 2. Revision: 7 January 20082. Revision received: 10 January 2007 Returned for 3. Revision: 14 January 20083. Revision received: 22 January 2008 Accepted: 29 January 2008 Published online: 7 April 2008
L. Lucats X. Monnet A. BizL. Hittinger A. Berdeaux B. Ghaleh (&) Laboratoire de Pharmacologie INSERM U 841 Equipe 03 Facult de Mdecine Universit Paris 128, rue du Gnral Sarrail 94010 Crteil Cedex, FranceTel.: 33-1/49-813593Fax: 33-1/49-981777E-Mail: [email protected]
L. Lucats X. Monnet A. BizV. Chetboul J.-L. PouchelonL. Hittinger A. Berdeaux B. Ghaleh INSERM U 841, Equipe 03, Ecole Nationale Vtrinaire dAlfort Maisons-Alfort, France
V. Chetboul J.-L. Pouchelon Unit de Cardiologie dAlfort Ecole Nationale Vtrinaire dAlfort Maisons-Alfort, France
L. Hittinger A. Berdeaux B. Ghaleh AP-HP Groupe hospitalier Henri Mondor-Albert Chenevier Fdration de CardiologieCrteil, France
j Abstract Aims Postsystolic wall thickening (PSWT) occurs after aortic valve closure. We investigated the inuence of ischemia location and wall interactions on PSWT in normal and stunned myocardium. Methods and results Twenty-two dogs were studied. Seven chronically instrumented dogs (sonomicrometry) underwent 10-min coronary artery occlusion (CAO) of left circumex artery (LCX stunning) and seven other dogs underwent 10-min CAO of the anterior descending artery (LAD stunning) followed by reperfusion. At baseline, there was no PSWT in the anterior wall whereas posterior wall started and nished to thicken after the anterior wall, demonstrating PSWT. With LCX stunning, PSWT was observed in the posterior wall without affecting the remote anterior wall. With LAD stunning, PSWT in the anterior wall was transient and of lower magnitude Vs. posterior wall; in the remote posterior wall, PSWT previously observed at baseline, almost vanished. Postsystolic to systolic wall thickening ratio identied (ROC analysis) normal, ischemic and stunned myocardium with different amplitudes between walls. Tissue Doppler Imaging demonstrated similar pattern in basal, mid and apical segments (additional n = 4 for both LCX and LAD stunning). Conclusion The present study demonstrates that location of ischemia...