Abstract

Epithelial ovarian carcinoma (EOC) is the most lethal gynecologic malignancy. However, the molecular mechanisms remain unclear. In this study, we found that miR-146b was downregulated in EOC and its expression level was negatively correlated with the pathological staging. Follow-up functional experiments illustrated that overexpression of miR-146b significantly inhibited cell migration and invasion, and increased cell proliferation, but it also improved the response to chemotherapeutic agents. Mechanistically, we demonstrated that miR-146b exerted its function mainly through inhibiting F-box and leucine-rich repeat protein 10 (FBXL10), and upregulated the Cyclin D1, vimentin (VIM), and zona-occludens-1 (ZO-1) expression in EOC. These findings indicate that miR-146b–FBXL10 axis is an important epigenetic regulation pathway in EOC. Low miR-146b may contribute to cancer progression from primary stage to advanced stage, and may be the promising therapeutic target of EOC.

Details

Title
miR-146b promotes cell proliferation and increases chemosensitivity, but attenuates cell migration and invasion via FBXL10 in ovarian cancer
Author
Yan, Meina 1 ; Yang, Xinxin 1 ; Shen, Rong 1 ; Wu, Chengjiang 1 ; Wang, Hui 1 ; Ye, Qing 2 ; Yang, Peifang 3 ; Lubin, Zhang 1 ; Chen, Miao 4 ; Wan, Bing 5 ; Zhang, Qinqin 6 ; Xia, Sheng 1 ; Lu, Xiaodong 1 ; Shao, Genbao 1 ; Zhou, Xiaoming 1 ; Yu, Jun 3 ; Shao, Qixiang 1   VIAFID ORCID Logo 

1  Department of Immunology, Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, China 
2  Department of Pathology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China 
3  Department of Gynecology and Obstetrics, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, China 
4  Department of Immunology, Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, China; Department of Pathology, Affiliated People’s Hospital of Jiangsu University, Zhenjiang, Jiangsu, China 
5  Department of ICU, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, China 
6  Department of Wuxi Maternal and Child Health Care Hospital, Wuxi, Jiangsu, China 
Pages
1-17
Publication year
2018
Publication date
Nov 2018
Publisher
Springer Nature B.V.
e-ISSN
20414889
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41419-018-1093-9
ProQuest document ID
2131225865
Copyright
© 2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.