Reactions of Immune System to Immobilization Stress in Inbred Mice of Different Strains

Abstract

Mice of different strains can be classified by the intensity of humoral immune reaction to thymus-dependent antigen as high, moderate, and low responders. High and moderate responders (CBA/CaLac, DBA/1, BALB/c) are characterized by high sensitivity of the productive phase of humoral immune response and phagocytic activity of macrophages to immobilization stress. In low responders (C57BL/6, CC57W) stress only slightly affected the productive phase of the humoral immune response, but activity of peritoneal macrophages decreased. These differences in the reactions of the immune system of inbred mice after immobilization stress reflect different reactions of the immune system to extreme factors.