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200Bulletin of Experimental Biology and Medicine, Vol. 137, No. 2, February, 2004MORPHOLOGY AND PATHOMORPHOLOGYPathomorphology of Vascular Bed in Different Variantsof Arrhythmogenic Heart DevelopmentV. D. Rozenberg and L. M. NepomnyashchikhTranslated from Byulleten Eksperimentalnoi Biologii i Meditsiny, Vol. 137, No. 2, pp. 225-230, February, 2004
Original article submitted October 14, 2003A total of 200 hearts from patients with various forms of cardiosclerosis and pronounced disorders of the heart rhythm were examined postmortem by contrast polypositional cardioventriculography, coronarography, volume and weight cardiometry, and morphometry. Left-ventricular, right-ventricular, and septal variants of arrhythmogenic heart development were distinguished. Left-ventricular variant is characterized by compensatory restructuring of the
vascular bed with appreciably increased volume of vascular density mainly in the left ventricle
and with the median left type of blood supply. The right-ventricular variant is characterized
by signs of compensation and decompensation of circulation and intensification of the right
ventricular vascularization. The septal variant is characterized by signs of vascular bed
decompensation with more intense vascularization of the septum. The detected diagnostic
criteria indicate appreciable structural rearrangement of the coronary bed of arrhythmogenic
heart, which explains the essential shifts in stimulation, contraction, and mechanical characteristics of the heart ventricles.Key Words: arrhythmogenic heart; vascular bed; coronarography; cardioventriculography; volume and weight cardiometryArrhythmogenic heart (AH) is now regarded as an
organ characterized by intricate and deep structural
rearrangement of the myocardium and nervous system
in response to lasting and variegated disorders in the
rhythmic activity [5]. Changes in the vascular bed play
an important role in the multifactorial process of AH
formation. Vascular disorders should be taken into
consideration in the diagnosis of the patho- and thanatogenesis. Such investigations are very important
because relatively individual variants of AH development were recently detected and each of these variants
is characterized by specific pathognomonic pathomorphological features.We studied changes in the vascular bed in different variants of AH development and distinguished the
criteria for pathomorphological diagnosis and some
thanatogenesis factors.MATERIALS AND METHODSA total of 200 hearts from dead patients (mean age56.40.4 years) with various forms of cardiosclerosis,
in whom pronounced arrhythmias were diagnosed during lifetime (during 10.20.2 years) were examined.
Ectopic arrhythmias (extrasystole and paroxysmal (extrasystolic) tachicardia) were recorded in 112 cases,
atrial and ventricular flutter and fibrillation in 28 cases.
Various conduction disorders were detected in 60