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Dig Dis Sci (2008) 53:636641 DOI 10.1007/s10620-007-9928-8
ORIGINAL PAPER
Gastric Emptying is Altered with the Presence of Gastritis
Erin L. Symonds Cuong D. Tran Ross N. Butler Taher I. Omari
Received: 26 February 2007 / Accepted: 9 July 2007 / Published online: 31 August 2007 Springer Science+Business Media, LLC 2007
Abstract Helicobacter pylori infection and gastritis can cause symptoms suggestive of altered gastrointestinal function; however, it is unclear if H. pylori inuences gastric motility. This study assessed gastric emptying rates in mouse models of gastritis. Gastritis was induced in C57BL/6 mice via ethanol treatment or via challenge withH. pylori or H. felis. Gastric emptying rates of nutrient and non-nutrient liquids were assessed with the non-invasive
13C-breath test, and the results were compared to healthy mice. Gastric emptying of the non-nutrient liquid was unaltered with the presence of gastritis; however, gastric emptying of the nutrient liquid was accelerated after a 4-week infection with H. pylori. H. felis infection and ethanol treatment caused a more severe gastritis and disruptions to the normal gastric emptying. Changes to gastric emptying in mouse models of gastritis are associated with the presence of nutrients. Altered gastric emptying may contribute to symptoms commonly reported in humans with gastritis.
Keywords Gastritis Gastric emptying
Helicobacter pylori 13C octanoic acid breath test
Introduction
Helicobacter pylori (H. pylori) infection is one of the most common bacterial infections worldwide, and it is associated with a variety of gastrointestinal problems, including gastritis, peptic and duodenal ulcer, gastric cancer, altered hormone and acid secretion, reduced gastric accommodation [1], and antral hypomotility [2]. As well as being caused by H. pylori infection, gastritis can be induced by drugs, such as non-steroidal anti-inammatory agents and alcohol. Inammatory reactions can cause various clinical manifestations frequently associated with abnormalities of the gastrointestinal tract, such as nausea, vomiting, or diarrhoea. Many of these gastrointestinal disturbances and symptoms of stomach pain, nausea and bloating, which are common with H. pylori infection and gastritis, suggest that there may also be an association with altered gastric emptying. Gastric emptying rates in patients with H. pylori induced gastritis has been previously investigated [39], but the ndings were contradictory. Thus, there are no denite conclusions as to whether H. pylori is able to inuence the motility of the...