Abstract

Royal jelly is the queen-maker for the honey bee Apis mellifera, and has cross-species effects on longevity, fertility, and regeneration in mammals. Despite this knowledge, how royal jelly or its components exert their myriad effects has remained poorly understood. Using mouse embryonic stem cells as a platform, here we report that through its major protein component Royalactin, royal jelly can maintain pluripotency by activating a ground-state pluripotency-like gene network. We further identify Regina, a mammalian structural analog of Royalactin that also induces a naive-like state in mouse embryonic stem cells. This reveals an important innate program for stem cell self-renewal with broad implications in understanding the molecular regulation of stem cell fate across species.

Details

Title
Honey bee Royalactin unlocks conserved pluripotency pathway in mammals
Author
Wan, Derrick C 1 ; Morgan, Stefanie L 2 ; Spencley, Andrew L 3 ; Mariano, Natasha 3 ; Chang, Erin Y 3 ; Shankar, Gautam 3 ; Luo, Yunhai 3 ; Li, Ted H 3 ; Huh, Dana 3 ; Huynh, Star K 3 ; Garcia, Jasmine M 3 ; Dovey, Cole M 4 ; Lumb, Jennifer 4 ; Liu, Ling 5 ; Brown, Katharine V 6 ; Bermudez, Abel 7 ; Luong, Richard 8 ; Zeng, Hong 9 ; Mascetti, Victoria L 9 ; Pitteri, Sharon J 7   VIAFID ORCID Logo  ; Wang, Jordon 10 ; Tu, Hua 10 ; Quarta, Marco 5 ; Sebastiano, Vittorio 9 ; Nusse, Roel 6 ; Rando, Thomas A 5 ; Carette, Jan E 4 ; Bazan, J Fernando 11 ; Wang, Kevin C 12   VIAFID ORCID Logo 

 Department of Dermatology, Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA, USA; Hagey Laboratory for Pediatric Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA 
 Department of Dermatology, Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA, USA; Program in Cancer Biology, Stanford University School of Medicine, Stanford, CA, USA 
 Department of Dermatology, Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA, USA 
 Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA, USA 
 The Glenn Laboratories for the Biology of Aging and Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA 
 Department of Developmental Biology, Howard Hughes Medical Institute, Stanford Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA 
 Canary Center for Cancer Early Detection, Department of Radiology, Stanford University School of Medicine, Palo Alto, CA, USA 
 Department of Comparative Medicine, Stanford University School of Medicine, Stanford, CA, USA 
 Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA 
10  LakePharma, Inc., Belmont, CA, USA 
11  R&D Systems, Inc, Minneapolis, MN, USA 
12  Department of Dermatology, Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA, USA; Program in Cancer Biology, Stanford University School of Medicine, Stanford, CA, USA; Veterans Affairs Palo Alto Healthcare System, Palo Alto, CA, USA 
Pages
1-9
Publication year
2018
Publication date
Dec 2018
Publisher
Nature Publishing Group
e-ISSN
20411723
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2148967570
Copyright
© 2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.