Abstract

Late diagnosis and ineffective treatment of fungal infections lead to high mortality. Here, Rudkin et al. generate anti-Candida human monoclonal antibodies with diagnostic and therapeutic potential, by expressing recombinant antibodies from genes cloned from B cells of patients suffering candidiasis.

Details

Title
Single human B cell-derived monoclonal anti-Candida antibodies enhance phagocytosis and protect against disseminated candidiasis
Author
Rudkin, Fiona M 1 ; Raziunaite, Ingrida 2 ; Workman, Hillary 3 ; Sosthene Essono 4 ; Belmonte, Rodrigo 5 ; MacCallum, Donna M 1   VIAFID ORCID Logo  ; Johnson, Elizabeth M 6 ; Silva, Lisete M 7 ; Palma, Angelina S 8 ; Ten Feizi 7 ; Jensen, Allan 9 ; Erwig, Lars P 10 ; Gow, Neil A R 11 

 Medical Research Council Centre for Medical Mycology at the University of Aberdeen, Aberdeen, UK 
 Medical Research Council Centre for Medical Mycology at the University of Aberdeen, Aberdeen, UK; Division of Infection and Immunity, The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK 
 Global Biotherapeutic Technologies, Pfizer Inc, Cambridge Kendall Square, Cambridge, MA, USA 
 Global Biotherapeutic Technologies, Pfizer Inc, Cambridge Kendall Square, Cambridge, MA, USA; HiFiBiO, Cambridge, MA, USA 
 Medical Research Council Centre for Medical Mycology at the University of Aberdeen, Aberdeen, UK; MSD Animal Health Innovation AS, Bergen, Norway 
 National Infection Service, PHE South West Laboratory, Science Quarter, Southmead Hospital, Bristol, UK 
 Glycosciences Laboratory, Department of Medicine, Imperial College London, Du Cane Road, UK 
 UCIBIO-REQUIMTE, Department of Chemistry, Faculty of Science and Technology, NOVA University of Lisbon, Lisbon, Portugal 
 Global Biotherapeutic Technologies, Pfizer Inc, Cambridge Kendall Square, Cambridge, MA, USA; H. Lundbeck, Valby, Denmark 
10  Medical Research Council Centre for Medical Mycology at the University of Aberdeen, Aberdeen, UK; Galvani Bioelectronics, Brentford, UK 
11  Medical Research Council Centre for Medical Mycology at the University of Aberdeen, Aberdeen, UK; School of Biosciences, University of Exeter, Exeter, UK 
Pages
1-16
Publication year
2018
Publication date
Dec 2018
Publisher
Nature Publishing Group
e-ISSN
20411723
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2154627892
Copyright
© 2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.