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Abstract
Late diagnosis and ineffective treatment of fungal infections lead to high mortality. Here, Rudkin et al. generate anti-Candida human monoclonal antibodies with diagnostic and therapeutic potential, by expressing recombinant antibodies from genes cloned from B cells of patients suffering candidiasis.
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1 Medical Research Council Centre for Medical Mycology at the University of Aberdeen, Aberdeen, UK
2 Medical Research Council Centre for Medical Mycology at the University of Aberdeen, Aberdeen, UK; Division of Infection and Immunity, The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, UK
3 Global Biotherapeutic Technologies, Pfizer Inc, Cambridge Kendall Square, Cambridge, MA, USA
4 Global Biotherapeutic Technologies, Pfizer Inc, Cambridge Kendall Square, Cambridge, MA, USA; HiFiBiO, Cambridge, MA, USA
5 Medical Research Council Centre for Medical Mycology at the University of Aberdeen, Aberdeen, UK; MSD Animal Health Innovation AS, Bergen, Norway
6 National Infection Service, PHE South West Laboratory, Science Quarter, Southmead Hospital, Bristol, UK
7 Glycosciences Laboratory, Department of Medicine, Imperial College London, Du Cane Road, UK
8 UCIBIO-REQUIMTE, Department of Chemistry, Faculty of Science and Technology, NOVA University of Lisbon, Lisbon, Portugal
9 Global Biotherapeutic Technologies, Pfizer Inc, Cambridge Kendall Square, Cambridge, MA, USA; H. Lundbeck, Valby, Denmark
10 Medical Research Council Centre for Medical Mycology at the University of Aberdeen, Aberdeen, UK; Galvani Bioelectronics, Brentford, UK
11 Medical Research Council Centre for Medical Mycology at the University of Aberdeen, Aberdeen, UK; School of Biosciences, University of Exeter, Exeter, UK