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Abstract
The apoE4 isoform is associated with increased cholesterol, cardiovascular risk, and Alzheimer’s Disease risk, however, its distribution is not well-understood among US Latinos. Latinos living in the US are highly Amerindian, European and African admixed, which varies by region and country of origin. However, Latino genetic diversity is understudied and consequently poorly understood, which has significant implications for understanding disease risk in nearly one-fifth of the US population. In this report we describe apoE distributions in a large and representative sample of diverse, genetically determined US Latinos.
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1 Department of Neurosciences and Shiley-Marcos Alzheimer’s Disease Research Center, University of California, San Diego, La Jolla, CA, USA
2 Institute of Gerontology & Department of Healthcare Sciences, Wayne State University, Detroit, Michigan, USA
3 Institute of Molecular Medicine, McGovern Medical School University of Texas Health Science Center, Houston, TX, USA
4 Albert Einstein, College of Medicine, New York, USA
5 Department of Laboratory Medicine and Pathology, University of Minnesota Medical Center Fairview, Minneapolis, Minnesota, USA
6 Institute for Minority Health Research, University of Illinois at Chicago, College of Medicine, Chicago, Illinois, USA
7 Rush University, Chicago, IL, USA
8 Institute for Behavioral and Community Health, Graduate School of Public Health, San Diego State University, San Diego, California, USA
9 Department of Biostatistics, Collaborative Studies Coordinating Center, University of North Carolina, Chapel Hill, North Carolina, USA
10 Institute of Molecular Medicine, McGovern Medical School University of Texas Health Science Center, Houston, TX, USA; Human Genetics Center, School of Public Health, University of Texas Health Science Center, Houston, TX, USA