Abstract

The meiotic telomere complex (MAJIN, TERB1, TERB2) tethers telomere ends to the nuclear envelope. Here the authors present the crystal structure of human MAJIN-TERB2 and combine biophysical approaches and structured illumination microscopy analysis of mouse meiotic chromosomes to characterize the molecular architecture of the wider MAJIN-TERB2-TERB1 complex and its interactions with TRF1.

Details

Title
Structural basis of meiotic telomere attachment to the nuclear envelope by MAJIN-TERB2-TERB1
Author
Dunce, James M 1 ; Milburn, Amy E 1 ; Manickam Gurusaran 1 ; da Cruz, Irene 2 ; Sen, Lee T 1 ; Benavente, Ricardo 2 ; Davies, Owen R 1   VIAFID ORCID Logo 

1  Institute for Cell and Molecular Biosciences, Faculty of Medical Sciences, Newcastle University, Framlington Place, Newcastle upon Tyne, UK 
2  Department of Cell and Developmental Biology, Biocenter, University of Würzburg, Würzburg, Germany 
Pages
1-18
Publication year
2018
Publication date
Dec 2018
Publisher
Nature Publishing Group
e-ISSN
20411723
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41467-018-07794-7
ProQuest document ID
2157867101
Copyright
© 2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.