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Abstract
Introduction
Efforts to lower glycosylated hemoglobin (A1c) in patients with type 2 diabetes (T2D) are intended to reduce the risk of diabetic complications, but A1c is not the only factor contributing to this risk. Consequently, we re-analyzed published data from a broad-spectrum lifestyle intervention that lowered A1c to assess its effectiveness in lowering the overall risk of two complications of T2D, namely, coronary heart disease (CHD) and stroke.
Methods
Data from 37 adults who participated in a randomized clinical trial of a lifestyle intervention intended to reduce postprandial glucose (PPG) were re-analyzed for their pre- and post-treatment risk of CHD and stroke using the T2D-specific UK Prospective Diabetes Study (UKPDS) v2.0 risk algorithm.
Results
Compared to participants who received routine care, those using the lifestyle intervention had a significantly greater reduction in 10-year risk for CHD, but not for stroke.
Conclusion
These secondary analyses suggest that broad-spectrum lifestyle interventions that focus on lowering PPG may lower the risk of future CHD, which could guide future research.
Trial Registration
ClinicalTrials.gov ID: NCT02432391.
Details
; Fang, Kun 2 ; McCall, Anthony L 3 ; Conaway, Mark R 4 ; Banton, Tom A 1 ; Moncrief, Matthew A 1 ; Diamond, Anne M 1 ; Taylor, Ann G 5 1 Department of Psychiatry and Neurobehavioral Sciences, Center for Behavioral Medicine Research, University of Virginia School of Medicine, Charlottesville, VA, USA
2 Department of Internal Medicine, Hospital of Xi’an Jiaotong University, Xi’an, Shaan’xi, China
3 Department of Endocrinology and Metabolism, University of Virginia School of Medicine, Charlottesville, VA, USA
4 Department of Public Health Sciences, University of Virginia School of Medicine, Charlottesville, VA, USA
5 Department of Acute and Specialty Care, University of Virginia School of Nursing, Charlottesville, VA, USA