Abstract

Recruitment of myeloid cells can be regulated by integrin CD11b. Here the authors show that in the tumor microenvironment, CD11b is not essential for recruitment of myeloid cells but rather induces macrophage anti-tumorigenic polarization via stimulating let7a and NFκB signaling and that pharmacological activation of CD11b enhances survival in mouse models of cancer.

Details

Title
Integrin CD11b activation drives anti-tumor innate immunity
Author
Schmid, Michael C 1 ; Khan, Samia Q 2 ; Kaneda, Megan M 1 ; Pathria, Paulina 1 ; Shepard, Ryan 1 ; Louis, Tiani L 1 ; Anand, Sudarshan 3   VIAFID ORCID Logo  ; Woo, Gyunghwi 1 ; Leem, Chris 1 ; Faridi, M Hafeez 2 ; Geraghty, Terese 2 ; Rajagopalan, Anugraha 2 ; Gupta, Seema 4 ; Ahmed, Mansoor 4 ; Vazquez-Padron, Roberto I 5 ; Cheresh, David A 3 ; Gupta, Vineet 2   VIAFID ORCID Logo  ; Varner, Judith A 6 

1  Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA 
2  Drug Discovery Center, Department of Internal Medicine, Rush University Medical Center, Chicago, IL, USA 
3  Department of Pathology, University of California, San Diego, La Jolla, CA, USA 
4  Department of Radiation Oncology, University of Miami Miller School of Medicine, Miami, FL, USA 
5  Department of Surgery, University of Miami Leonard M. Miller School of Medicine, Miami, USA 
6  Moores Cancer Center, University of California, San Diego, La Jolla, CA, USA; Department of Pathology, University of California, San Diego, La Jolla, CA, USA 
Pages
1-14
Publication year
2018
Publication date
Dec 2018
Publisher
Nature Publishing Group
e-ISSN
20411723
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41467-018-07387-4
ProQuest document ID
2158542525
Copyright
© 2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.