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Copyright © 2019 Zonglei Zhou et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0/

Abstract

Background. Several studies have investigated the association between Toxoplasma gondii (T. gondii) infection and risk of Parkinson’s disease (PD) with inconsistent results. Clarifying this relation might be useful for better understanding of the risk factors and the relevant mechanisms of PD, thus a meta-analysis was conducted to explore whether exposure to T. gondii is associated with an increased risk of PD. Methods. We conducted this meta-analysis according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. A rigorous literature selection was performed by using the databases of PubMed, Embase, Web of Science, Cochrane Library, and ScienceDirect. Odds ratio (OR) and corresponding 95% confidential interval (CI) were pooled by using fixed-effects models. Sensitivity analysis, publication bias test, and methodological quality assessment of studies were also performed. Results. Seven studies involving 1086 subjects were included in this meta-analysis. Pooled data by using fixed-effects models suggested both latent infection (OR, 1.17; 95% CI, 0.86 to 1.58; P=0.314) and acute infection (OR, 1.13; 95% CI, 0.30 to 4.35; P=0.855) were not associated with PD risk. Stable and robust estimates were confirmed by sensitivity analysis. No publication bias was found by visual inspection of the funnel plot, Begg’s, and Egger’s test. Conclusions. This meta-analysis does not support any possible association between T. gondii infection and risk of PD. Researches are still warranted to further explore the underlying mechanisms of T. gondii in the pathogenesis of PD and their causal relationship.

Details

Title
The Association between Toxoplasma gondii Infection and Risk of Parkinson’s Disease: A Systematic Review and Meta-Analysis
Author
Zhou, Zonglei 1 ; Zhou, Ruzhen 2 ; Li, Kunpeng 3   VIAFID ORCID Logo  ; Wen, Wei 1 ; Zhang, Zengqiao 4 ; Zhu, Yan 3 ; Luan, Rongsheng 1   VIAFID ORCID Logo 

 Department of Epidemiology and Biostatistics, Sichuan University West China School of Public Health, Chengdu 610041, Sichuan Province, China 
 Department of Anorectal Surgery, Changhai Hospital of Shanghai, Shanghai 200433, China 
 Department of Neurorehabilitation, Shanghai Second Rehabilitation Hospital, Shanghai 200441, China 
 School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China 
Editor
Nicola Simola
Publication year
2019
Publication date
2019
Publisher
John Wiley & Sons, Inc.
ISSN
23146133
e-ISSN
23146141
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2189478479
Copyright
Copyright © 2019 Zonglei Zhou et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0/