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Abstract
Many studies showed that several diseases including diabetes mellitus DM are directly implicated in the elevating of acetylcholinesterase ACHE activity in most biological fluids and considered as a risk factor for neuronal death causing many degenerative disorders involving dementia. The most common dementia lesions related to DM are Alzheimer's disease AD. Metformin is currently as a first-line oral therapy for T2DM and considered a prophylactic factor to prevent of diabetic development. It lowers the AChE efficacy , that directs for the neurotransmitter ( Ach) dissociation. The current investigation involves a study the effect of metformin on the activity of ACHE and some clinical variables for T2DM patients taken metformin monotherapy and combined to insulin of Iraqi population.
Methods : study population was 65 patients with type 2 diabetes and 22 healthy control subjects were age (42-80) year. The patients groups were distributed in three groups. The first had newly disease diagnosis without therapy , second had orally metformin monotherapy and the third had injected insulin with orally metformin as a combination therapy. The activity of acetylcholinesterase AChE and clinical biochemical tests ( FBG, HbA1c% , BMI , and lipid profile ) were assessed . Duration of disease and therapy and body mass index had been obtained from patients directly during their attending to the National Center of Diabetes in AL-Mustansyria University in Baghdad / Iraq.
Results: No significant difference in the AChE enzyme, BMI, TG, therapy duration and significant difference in age, FPG, HbA1c%, disease duration, T.CH, HDL, and LDL.
Conclusion: it was concluded that metformin drug lowers the activity of enzyme to the extent that had been appeared close to the normal activity values enzyme for healthy people in either monotherapy or combined therapy. As well as, it was more efficacy in male than female at all the studied variables for this investigation.
Keywords : Acetylcholinesterase Enzyme, Diabetes Mellitus, Dementia , Insulin, Metformin.
Introduction
Diabetes mellitus DM is a chronic metabolic defect that is known as a hyperglycemia with disorders in carbohydrates, fats and proteins metabolism created from the deficiency in insulin releasing, insulin efficacy or both, appears as a consequence of many complicated actions of genetic, ecological agents , and lifestyle options [1] , [2]. Morbidity and mortality caused by DM...