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Abstract
Helicobacter pylori infection is associated with high incidence of gastric diseases. The extensive therapy of H. pylori infection with antibiotics has increased its resistance rates worldwide. Ovatodiolide, a pure constituent isolated from Anisomeles indica, has been demonstrated to possess bactericidal activity against H. pylori. In this study, ovatodiolide inhibited the growth of both H. pylori reference strain and clinical multidrug-resistant isolates. Docking analysis revealed that ovatodiolide fits into the hydrophobic pocket of a ribosomal protein, RpsB. Furthermore, ovatodiolide inhibited bacterial growth by reducing levels of RpsB, which plays a crucial role in protein translation. Our results demonstrate that ovatodiolide binds to a ribosomal protein and interferes with protein synthesis. This study provides evidence that ovatodiolide has the potential to be developed into a potent therapeutic agent for treating H. pylori infection.
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Details
1 Research Institute of Biotechnology, Hungkuang University, Taichung, Taiwan (GRID:grid.411432.1) (ISNI:0000 0004 1770 3722)
2 Department of Biochemistry, Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Department of Microbiology and Immunology, Taoyuan, Taiwan (GRID:grid.145695.a)
3 Industrial Technology Research Institute, Targeted Drug and Delivery Technology Division, Biomedical Technology and Device Research Laboratories, Hsinchu, Taiwan (GRID:grid.418030.e) (ISNI:0000 0001 0396 927X)
4 Molecular Infectious Disease Research Center, Chang Gung Memorial Hospital, Department of Pediatrics, Department of Neurology, Linkou, Taiwan (GRID:grid.418030.e)
5 Department of Biochemistry, Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Department of Microbiology and Immunology, Taoyuan, Taiwan (GRID:grid.145695.a); Molecular Infectious Disease Research Center, Chang Gung Memorial Hospital, Department of Pediatrics, Department of Neurology, Linkou, Taiwan (GRID:grid.145695.a)
6 Molecular Science Center, Genetics Generation Advancement, Taipei, Taiwan (GRID:grid.145695.a)
7 National Chung Hsing University, Department of Life Sciences, Taichung, Taiwan (GRID:grid.260542.7) (ISNI:0000 0004 0532 3749)
8 Dachien General Hospital, Department of Rehabilitation, Miaoli, Taiwan (GRID:grid.260542.7)
9 Feng Chia University, School of Management, Taichung, Taiwan (GRID:grid.411298.7) (ISNI:0000 0001 2175 4846)
10 Taipei Medical University, Division of Gastroenterology and Hepatology, Department of Internal Medicine, School of Medicine, College of Medicine, Taipei, Taiwan (GRID:grid.412896.0) (ISNI:0000 0000 9337 0481); Department of Internal Medicine, Shuang-Ho Hospital, Division of Gastroenterology and Hepatology, New Taipei, Taiwan (GRID:grid.412896.0)
11 Department of Biochemistry, Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Department of Microbiology and Immunology, Taoyuan, Taiwan (GRID:grid.145695.a); Molecular Infectious Disease Research Center, Chang Gung Memorial Hospital, Department of Pediatrics, Department of Neurology, Linkou, Taiwan (GRID:grid.145695.a); Asia University, Department of Nursing, Taichung, Taiwan (GRID:grid.252470.6) (ISNI:0000 0000 9263 9645); China Medical University and Hospital, School of Medicine, Department of Medical Research, Taichung, Taiwan (GRID:grid.411508.9) (ISNI:0000 0004 0572 9415)