Abstract

Heroin use disorder (HUD) is a complex disease resulting from interactions among genetic and other factors (e.g., environmental factors). The mechanism of HUD development remains unknown. Newly developed network medicine tools provide a platform for exploring complex diseases at the system level. This study proposes that protein–protein interactions (PPIs), particularly those among proteins encoded by casual or susceptibility genes, are extremely crucial for HUD development. The giant component of our constructed PPI network comprised 111 nodes with 553 edges, including 16 proteins with large degree (k) or high betweenness centrality (BC), which were further identified as the backbone of the network. JUN with the largest degree was suggested to be central to the PPI network associated with HUD. Moreover, PCK1 with the highest BC and MAPK14 with the secondary largest degree and 9th highest BC might be involved in the development HUD and other substance diseases.

Details

Title
Construction and Analysis of Protein-Protein Interaction Network of Heroin Use Disorder
Author
Shaw-Ji, Chen 1 ; Ding-Lieh, Liao 2 ; Chia-Hsiang, Chen 3   VIAFID ORCID Logo  ; Tse-Yi, Wang 4 ; Kuang-Chi, Chen 4 

1  Mackay Medical College, Department of Medicine, New Taipei City, Taiwan (GRID:grid.452449.a) (ISNI:0000 0004 1762 5613); Mackay Memorial Hospital, Department of Psychiatry, Taitung Branch, Taiwan (GRID:grid.413593.9) (ISNI:0000 0004 0573 007X) 
2  Bali Psychiatric Center, Department of Health, Executive Yuan, New Taipei, Taiwan (GRID:grid.452230.2) (ISNI:0000 0004 0638 6338) 
3  Chang Gung Memorial Hospital at Linkou and Chang Gung University School of Medicine, Department of Psychiatry, Taoyuan, Taiwan (GRID:grid.145695.a) 
4  Tzu Chi University, Department of Medical Informatics, Hualien, Taiwan (GRID:grid.411824.a) (ISNI:0000 0004 0622 7222) 
Publication year
2019
Publication date
Dec 2019
Publisher
Nature Publishing Group
e-ISSN
20452322
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41598-019-41552-z
ProQuest document ID
2195267473
Copyright
This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.