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Abstract
Chitin-glucan (CG) represents a natural carbohydrate source for certain microbial inhabitants of the human gut and may act as a prebiotic for a number of bacterial taxa. However, the bifidogenic activity of this substrate is still unknown. In the current study, we evaluated the ability of chitin-glucan to influence growth of 100 bifidobacterial strains belonging to those species commonly identified within the bifidobacterial communities residing in the infant and adult human gut. Such analyses were coupled with transcriptome experiments directed to explore the transcriptional effects of CG on Bifidobacterium breve 2L, which was shown to elicit the highest growth performance on this natural polysaccharide. In addition, an in vivo trial involving a rat model revealed how the colonization efficiency of this bifidobacterial strain was enhanced when the animals were fed with a diet containing CG. Altogether our analyses indicate that CG is a valuable novel prebiotic compound that may be added to the human diet in order to re-establish/reinforce bifidobacteria colonization in the mammalian gut.
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1 University of Parma, Department of Veterinary Medical Science, Parma, Italy (GRID:grid.10383.39) (ISNI:0000 0004 1758 0937)
2 Life Sciences, and Environmental Sustainability, University of Parma, Laboratory of Probiogenomics, Department of Chemistry, Parma, Italy (GRID:grid.10383.39) (ISNI:0000 0004 1758 0937)
3 KitoZyme, Herstal, Belgium (GRID:grid.425606.3)
4 Life Sciences and Environmental Sustainability, University of Parma, Stress Physiology Laboratory, Department of Chemistry, Parma, Italy (GRID:grid.10383.39) (ISNI:0000 0004 1758 0937)
5 National University of Ireland, APC Microbiome Institute and School of Microbiology, Bioscience Institute, Cork, Ireland (GRID:grid.7872.a) (ISNI:0000000123318773)