Abstract

The engineering of surface patterns is a powerful tool for analyzing cellular communication factors involved in the processes of adhesion, migration, and expansion, which can have a notable impact on therapeutic applications including tissue engineering. In this regard, the main objective of this research was to fabricate patterned and textured surfaces at micron- and nanoscale levels, respectively, with very different chemical and topographic characteristics to control cell–substrate interactions. For this task, one-dimensional (1-D) and two-dimensional (2-D) patterns combining silicon and nanostructured porous silicon were engineered by ion beam irradiation and subsequent electrochemical etch. The experimental results show that under the influence of chemical and morphological stimuli, human mesenchymal stem cells polarize and move directionally toward or away from the particular stimulus. Furthermore, a computational model was developed aiming at understanding cell behavior by reproducing the surface distribution and migration of human mesenchymal stem cells observed experimentally.

Details

Title
Engineering of silicon surfaces at the micro- and nanoscales for cell adhesion and migration control
Author
Torres-Costa, Vicente; Martínez-Muñoz, Gonzalo; Sánchez-Vaquero, Vanessa; Muñoz-Noval, Álvaro; González-Méndez, Laura; Punzón-Quijorna, Esther; Gallach-Pérez, Darío; Manso-Silván, Miguel; Climent-Font, Aurelio; García-Ruiz, Josefa P; Martín-Palma, Raúl J
Pages
623-630
Section
Original Research
Publication year
2012
Publication date
2012
Publisher
Taylor & Francis Ltd.
ISSN
1176-9114
e-ISSN
1178-2013
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2222533396
Copyright
© 2012. This work is licensed under https://creativecommons.org/licenses/by-nc/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.