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ABSTRACT
Microwave assisted organic synthesis (MAOS) has emerged as frontier in pharmaceutical research for synthesis of newer drugs. MAOS help not only in implementing GREEN chemistry but also led to the revolution in organic synthesis. For this purpose Methyl 2-acetoamidobenzoate was synthesized using methyl Anthranilate and acetic anhydride in presence of catalytic pyridine. Methyl 2-acetoamidobenzoate treated with different bases like ammonia, hydrazine hydrate to yield 2-methyl-3(H)-quinazolinone and 2- methyl-3-amino-4-quinazolinone respectively. The microwave irradiation has resulted high product yields and reduced reaction times.
KEY WORDS: acetamide, microwave, quinazolinone
Introduction
Quinazoline-4(3H)-ones and its derivatives are versatile nitrogen heterocyclic compounds which have long been known as a promising class of biologically active compounds [1,2]. Quinazolinone are excellent reservoir of bioactive substances. The stability of the Quinazoline nucleus has inspired medicinal chemists to introduce many bioactive moieties to this nucleus to synthesize new potential medicinal agents. Quinazoline is 1, 3- diazanaphthalene. It is also known as 5, 6-benzopyrimidine [3] and its 4-oxo derivative are called 4(3H)- quinazolinone 4-6. Quinazolin-4(3H)-ones are also important building blocks in the synthesis of natural and pharmacological compounds7. The Quinazoline skeleton, when selectively functionalized, is a building block for the preparation of numerous alkaloids and substances with pronounced biological activities. Various approaches toward the synthesis of quinazolin- 4(3H)-one derivatives have been explored during the past years. Recent progress in quinazoline alkaloids and related chemistry was...