Abstract
Background: The present study was conducted to determine antimicotic susceptibility of Candida species (sp.) from patients with symptomatic candiduria. Materials and Methods: Identification of Candida sp. and determination of efficacy of most routine antifungals were done using polymerase chain reaction-restriction fragment length polymorphism method and E-test, respectively. Results: The results from susceptibility test reveal that caspofungin and amphotericin B have high antifungal activity against both albicans (100% and 96%, respectively) and nonalbicans (95.11% and 72.72%, respectively) isolates. Conclusion: The present study suggests that caspofungin and amphotericin B have the excellent ability to eradicate both Candida groups that showed decreased susceptibility to other compounds.
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Details
1 Research Center of Pediatric Infectious Diseases, Institute of Immunology and Infectious Diseases; Department of Infectious Disease, Rasul-e Akram Hospital, Iran University of Medical Sciences, Tehran
2 Department of Microbiology, Faculty of Medicine; Microbiol Biotechnology Research Center, Iran University of Medical Sciences, Tehran
3 Department of Parasitology and Mycology, School of Medicine, Shahid Beheshti University of Medical Scienses, Tehran
4 Student Research Committee, Kerman University of Medical Sciences; Department of Medical Mycology and Parasitology, School of Medicine, Medical University of Kerman, Kerman
5 Center for Research and Training in Skin Disease and Leprosy, Tehran University of Medical Sciences, Tehran