Abstract

Growth failure during infancy is a major global problem that has adverse effects on long-term health and neurodevelopment. Preterm infants are disproportionately affected by growth failure and its effects. Herein we found that extremely preterm infants with postnatal growth failure have disrupted maturation of the intestinal microbiota, characterized by persistently low diversity, dominance of pathogenic bacteria within the Enterobacteriaceae family, and a paucity of strictly anaerobic taxa including Veillonella relative to infants with appropriate postnatal growth. Metabolomic profiling of infants with growth failure demonstrated elevated serum acylcarnitines, fatty acids, and other byproducts of lipolysis and fatty acid oxidation. Machine learning algorithms for normal maturation of the microbiota and metabolome among infants with appropriate growth revealed a pattern of delayed maturation of the microbiota and metabolome among infants with growth failure. Collectively, we identified novel microbial and metabolic features of growth failure in preterm infants and potentially modifiable targets for intervention.

Details

Title
Disrupted Maturation of the Microbiota and Metabolome among Extremely Preterm Infants with Postnatal Growth Failure
Author
Younge, Noelle E 1 ; Newgard, Christopher B 2 ; Michael, Cotten C 1 ; Goldberg, Ronald N 1 ; Muehlbauer, Michael J 3 ; Bain, James R 4   VIAFID ORCID Logo  ; Stevens, Robert D 4 ; O’Connell Thomas M 5 ; Rawls, John F 6 ; Seed, Patrick C 7 ; Ashley, Patricia L 1 

1  Duke University, Division of Neonatology, Department of Pediatrics, Durham, USA (GRID:grid.26009.3d) (ISNI:0000 0004 1936 7961) 
2  Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University, Durham, USA (GRID:grid.26009.3d) (ISNI:0000 0004 1936 7961); Duke University, Department of Pharmacology and Cancer Biology, Durham, USA (GRID:grid.26009.3d) (ISNI:0000 0004 1936 7961); Duke University, Division of Endocrinology and Metabolism, Department of Medicine, Durham, USA (GRID:grid.26009.3d) (ISNI:0000 0004 1936 7961) 
3  Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University, Durham, USA (GRID:grid.26009.3d) (ISNI:0000 0004 1936 7961) 
4  Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University, Durham, USA (GRID:grid.26009.3d) (ISNI:0000 0004 1936 7961); Duke University, Division of Endocrinology and Metabolism, Department of Medicine, Durham, USA (GRID:grid.26009.3d) (ISNI:0000 0004 1936 7961) 
5  Duke Molecular Physiology Institute and Sarah W. Stedman Nutrition and Metabolism Center, Duke University, Durham, USA (GRID:grid.26009.3d) (ISNI:0000 0004 1936 7961); Head and Neck Surgery, Indiana University, Department of Otolaryngology, Indianapolis, USA (GRID:grid.257413.6) (ISNI:0000 0001 2287 3919) 
6  Duke University, Department of Molecular Genetics and Microbiology, Durham, USA (GRID:grid.26009.3d) (ISNI:0000 0004 1936 7961) 
7  Northwestern University, Department of Pediatrics, Chicago, USA (GRID:grid.16753.36) (ISNI:0000 0001 2299 3507) 
Publication year
2019
Publication date
2019
Publisher
Nature Publishing Group
e-ISSN
20452322
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41598-019-44547-y
ProQuest document ID
2233825999
Copyright
© The Author(s) 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.