Abstract

To enrich the bioactive cycloartane triterpenoid glycoside named actein and find out more cytotoxic cycloartane triterpenes, a phytochemical study of Cimicifuga foetida was conducted. 113 g (0.17%) actein was purified by recrystallization while eight cycloartane-type triterpenes (18) were isolated from the mother liquid. The chemical structures of new compounds (14) were elucidated by 1D and 2D NMR and HRESIMS spectroscopic analyses. Moreover, new compounds showed moderate and broad-spectrum cytotoxicity against 5 human cancer cell lines with IC50 values ranging from 4.02 to 15.80 μM.

Graphic Abstract

Details

Title
Cytotoxic Cycloartane Triterpenoid Saponins from the Rhizomes of Cimicifuga foetida
Author
Lu, Jing 1 ; Xing-Rong, Peng 2 ; Da-Shan, Li 2 ; Qiang-Qiang Shi 1 ; Ming-Hua Qiu 3 

 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences (CAS), Kunming, People’s Republic of China; University of Chinese Academy of Sciences, Beijing, China 
 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences (CAS), Kunming, People’s Republic of China 
 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences (CAS), Kunming, People’s Republic of China; University of Chinese Academy of Sciences, Beijing, China; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, People’s Republic of China 
Pages
303-310
Publication year
2019
Publication date
Aug 2019
Publisher
Springer Nature B.V.
ISSN
21922195
e-ISSN
21922209
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2242646364
Copyright
Natural Products and Bioprospecting is a copyright of Springer, (2019). All Rights Reserved., © 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.