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AT A GLANCE
BULLOUS PEMPHIGOID
Clinical features
*Uncommon chronic autoimmune disease.
* Most common in middle-aged and elderly.
* IgG immunoglobulin and activated T-lymphocytes attack components of the basement membrane, causing separation of keratinocytes from the dermis.
* May present with itchy eczematous or urticarial rash prior to blistering.
* Crops of tense blisters, filled with clear or blood-stained fluid. Lesions heal without scarring.
* Localised or widespread.
* Mucosal ulceration in 10-25 per cent of cases.
* Untreated may persist for months or years with remissions and exacerbations. Usually settles...