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Neuropsychopharmacology (2003) 28, 22102211

Weight Gain for Typical and Atypical Antipsychotic Drugs[notdef]

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[notdef]Wesley K Kroeze*,1,2, Sandra J Hufeisen2, Beth A Popadak2, Sean M Renock2, SeAnna Steinberg2, Paul

Ernsberger3,4, Karu Jayathilake5,6, Herbert Y Meltzer5,6 and Bryan L Roth1,2,7,81Department of Biochemistry, Case Western Reserve University Medical School, Cleveland, OH, USA; 2NIMH Psychoactive Drug ScreeningProgram, Case Western Reserve University Medical School, Cleveland, OH, USA;3Department of Nutrition, Case Western Reserve UniversityMedical School, Cleveland, OH, USA;4Department of Pharmacology, Case Western Reserve University Medical School, Cleveland, OH, USA;5Department of Psychiatry, Vanderbilt University Medical School, Nashville, TN, USA; 6Department of Pharmacology, Vanderbilt UniversityMedical School, Nashville, TN, USA;7Department of Psychiatry, Case Western Reserve University, Medical School, Cleveland, OH, USA;8Department of Neurosciences, Case Western Reserve University, Medical School, Cleveland, OH, USANeuropsychopharmacology (2003) 28, 22102211, advance online publication, 27 August 2003; doi:10.1038/sj.npp.1300292Sir

We thank the correspondents for their interest in our work

(Kroeze et al, 2003), and are grateful for the opportunity to

respond to their comments. They correctly summarize the

major conclusion of our paper, that is, that affinity for the

H1-histamine receptor is the best predictor of a drugs

propensity to induce weight gain. It is not the only

predictor, however, since affinities for the a-1a adrenergic

and the 5-HT2c serotonin receptor, among others, were...

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