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Abstract

Indole-3-carbaldehyde (1) was isolated as a tyrosinase inhibitor from the ethyl acetate-soluble fraction of extracellular fluids of unknown fungus YL185. The partial sequencing data of 18S ribosomal DNA (18S rDNA) indicate that this isolate belongs to the family Polyporaceae or Corticiaceae sensu lato. Indole-3-carbaldehyde inhibited the oxidation of l-3,4-dihydroxyphenylalanine (l-DOPA) by mushroom tyrosinase with a 50% inhibitory concentration (IC50) of 1.3 mM and showed inhibitory activity on melanin production in B16 melanoma cells. The aldehyde group of 1 plays an important role in eliciting tyrosinase inhibitory activity.

Details

Title
Indole-3-carbaldehyde: a tyrosinase inhibitor from fungus YL185
Author
Shimizu, Kuniyoshi 1 ; Geng, Xinglian 1 ; Hashiguchi, Mika 1 ; Suhara, Hiroto 1 ; Fukunaga, Syoko 1 ; Yasutake, Seiji 1 ; Kondo, Ryuichiro 1 ; Tsutsui, Mototake 2 ; Sato, Ikuo 2 

1  Department of Forest and Forest Products Sciences, Faculty of Agriculture, Kyushu University, Fukuoka, Japan 
2  Chisso Corporation, Yokohama, Japan 
Pages
349-354
Publication year
2003
Publication date
Aug 2003
Publisher
Springer Nature B.V.
ISSN
14350211
e-ISSN
16114663
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1007/s10086-002-0484-8
ProQuest document ID
2259403612
Copyright
Journal of Wood Science is a copyright of Springer, (2003). All Rights Reserved.