Abstract

The Therapeutic Structural Antibody Database (Thera-SabDab; http://opig.stats.ox.ac.uk/webapps/therasabdab) tracks all antibody- and nanobody-related therapeutics recognised by the World Health Organisation (WHO), and identifies any corresponding structures in the Structural Antibody Database (SAbDab) with near-exact or exact variable domain sequence matches. Thera-SAbDab is synchronised with SAbDab to up-date weekly, reflecting new Protein Data Bank entries and the availability of new sequence data published by the WHO. Each therapeutic summary page lists structural coverage (with links to the appropriate SAbDab entries), alignments showing where any near-matches deviate in sequence, and accompanying metadata, such as intended target and investigated conditions. Thera-SAbDab can be queried by therapeutic name, by a combination of metadata, or by variable domain sequence - returning all therapeutics that are within a specified sequence identity over a specified region of the query. The sequences of all therapeutics listed in Thera-SAbDab (461 unique molecules, as of 18th July 2019) are downloadable as a single file with accompanying metadata.

Footnotes

* Corrected citation for Ixekizumab/Tibulizumab study. Updated statistics. Minor text changes.

Details

Title
Thera-SAbDab: the Therapeutic Structural Antibody Database
Author
Raybould, Matthew I J; Marks, Claire; Lewis, Alan P; Shi, Jiye; Bujotzek, Alexander; Bruck Taddese; Deane, Charlotte
University/institution
Cold Spring Harbor Laboratory Press
Section
New Results
Publication year
2019
Publication date
Aug 12, 2019
Publisher
Cold Spring Harbor Laboratory Press
ISSN
2692-8205
Source type
Working Paper
Language of publication
English
DOI
https://doi.org/10.1101/707521
ProQuest document ID
2259815332
Copyright
© 2019. This article is published under http://creativecommons.org/licenses/by/4.0/ (“the License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.