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Abstract:
Emulgel is the recent technology in novel drug delivery system used for control release of emulsion and gel for the purpose of topical use. The stability of emulsion is increased, when it is incorporated into gel. Ketoconazole is a lipophilic antifungal drug has been used in the treatment of dermatophytic infection. The goal of the present study was to design and Characterisation of Emulgel of an Antifungal Ketoconazole drug to incorporate hydrophobic or poorly water soluble drug in formulation and delivered through gels and which will increase skin penetration of drug. This study was conducted to develop emulgel formulations of Ketoconazole using different types of gelling agents like carbapol 940 and carbopol 934. The in-vitro diffusion studies were carried out for all formulations. All gels showed acceptable results of properties like color, homogeneity, consistency, pH, viscosity, spreadability, extrudability and drug content etc. Formulation containing Carbapol 934 having good spreadability, homogeneity and soothening effect. In these all aspect the formulation F5 satisfied all the pharmaceutical parameter of emulgel and appears to be good topical agent.
Keywords: Ketoconazole (Ktz), Topical Drug Delivery System, Emulgel, Carbopol 934, Carbapol 940
I.Introduction
Topical drug delivery is the term used for localized treatment of dermatological condition where the medication is not targeted for systemic delivery; examples include treatment of dermatological conditions like eczema or psoriasis by topical application. Examples of drugs delivered topically include corticosteroids, antifungals, antivirals, antibiotics, antiseptics, local anesthetics, and antineoplastics.
Gels being newer class of dosage form are created by entrapment of large amounts of aqueous or hydro alcoholic liquid in a network of colloidal solid particles, which may obtained from natural or synthetic origin. The higher constitution of aqueous component shows greater dissolution of drugs, and permits easy migration of the drug through a liquid vehicle as compared with the ointment or cream base. In spite to advantageous gels show a major limitation in the delivery of hydrophobic drugs. So avoid this limitation, emulgel is prepared. In fact, the presence of a gelling agent in the water phase converts a classical emulsion into an emulgel. To deliver the various drugs to the skin, both oil-in-water and waterin-oil type of emulsions are used as vehicles.
For dermatological use Emulgels show several favorable properties such as being...