Details
Title
Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits
Author
Porcu, Eleonora 1
; Rüeger, Sina 2
; Lepik, Kaido 3
; Agbessi, Mawussé 4 ; Ahsan, Habibul 5 ; Alves, Isabel 4 ; Andiappan, Anand 6 ; Wibowo Arindrarto 7 ; Awadalla, Philip 4 ; Battle, Alexis 8 ; Beutner, Frank 9 ; Bonder, Marc Jan 10 ; Boomsma, Dorret 11 ; Christiansen, Mark 12 ; Claringbould, Annique 13 ; Deelen, Patrick 14 ; Tõnu Esko 15 ; Marie-Julie Favé 16 ; Franke, Lude 13 ; Frayling, Timothy 17 ; Gharib, Sina A 18 ; Gibson, Gregory 19 ; Heijmans, Bastiaan T 7 ; Gibran Hemani 20 ; Jansen, Rick 21 ; Kähönen, Mika 22 ; Kalnapenkis, Anette 15 ; Silva Kasela 15 ; Kettunen, Johannes 23 ; Kim, Yungil 24 ; Kirsten, Holger 25 ; Kovacs, Peter 26 ; Krohn, Knut 27 ; Kronberg-Guzman, Jaanika 15 ; Kukushkina, Viktorija 15 ; Lee, Bernett 6 ; Lehtimäki, Terho 28 ; Loeffler, Markus 25 ; Marigorta, Urko M 19 ; Hailang Mei 7 ; Milani, Lili 15 ; Montgomery, Grant W 29 ; Müller-Nurasyid, Martina 30 ; Nauck, Matthias 31 ; Nivard, Michel 11 ; Penninx, Brenda 22 ; Perola, Markus 32 ; Pervjakova, Natalia 15 ; Pierce, Brandon L 5 ; Powell, Joseph 33 ; Prokisch, Holger 34 ; Psaty, Bruce M 35 ; Raitakari, Olli T 36 ; Ripatti, Samuli 37 ; Rotzschke, Olaf 6 ; Saha, Ashis 16 ; Scholz, Markus 25 ; Schramm, Katharina 38 ; Seppälä, Ilkka 28 ; Slagboom, Eline P 7 ; Stehouwer, Coen D A 39 ; Stumvoll, Michael 40 ; Sullivan, Patrick 41 ; Peter A C ‘t Hoen 42 ; Teumer, Alexander 43 ; Thiery, Joachim 44 ; Lin, Tong 5 ; Tönjes, Anke 40 ; Jenny van Dongen 11 ; Maarten van Iterson 7 ; Joyce van Meurs 45 ; Veldink, Jan H 46 ; Verlouw, Joost 45 ; Visscher, Peter M 29 ; Völker, Uwe 47 ; Võsa, Urmo 48 ; Harm-Jan Westra 13 ; Wijmenga, Cisca 13 ; Yaghootkar, Hanieh 17 ; Yang, Jian 49 ; Zeng, Biao 19 ; Zhang, Futao 29 ; Beekman, Marian 50 ; Boomsma, Dorret I 11 ; Bot, Jan 51 ; Deelen, Joris 50 ; Peter A C ’t Hoen 52 ; Hofman, Bert A 53 ; Hottenga, Jouke J 11 ; Isaacs, Aaron 54 ; P Mila Jhamai 55 ; Kielbasa, Szymon M 56 ; Lakenberg, Nico 50 ; Luijk, René 50 ; Mei, Hailiang 57 ; Moed, Matthijs 50 ; Nooren, Irene 51 ; Pool, René 11 ; Schalkwijk, Casper G 58 ; P Eline Slagboom 50 ; H Eka D Suchiman 50 ; Swertz, Morris A 59 ; Tigchelaar, Ettje F 13 ; Uitterlinden, André G 45 ; Leonard H van den Berg 51 ; Ruud van der Breggen 50 ; Carla J H van der Kallen 58 ; Freerk van Dijk 59 ; van Duijn, Cornelia M 54 ; Michiel van Galen 52 ; Marleen M J van Greevenbroek 58 ; Diana van Heemst 60 ; Jeroen van Rooij 45 ; Peter van’t Hof 57 ; van Zwet, Erik W 56 ; Vermaat, Martijn 52 ; Verbiest, Michael 45 ; Verkerk, Marijn 45 ; Zhernakova, Dasha V 13 ; Zhernakova, Sasha 13 ; Santoni, Federico A 61 ; Reymond, Alexandre 62 ; Kutalik, Zoltán 2
1 Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland; Swiss Institute of Bioinformatics, Lausanne, Switzerland
2 Swiss Institute of Bioinformatics, Lausanne, Switzerland; University Center for Primary Care and Public Health, University of Lausanne, Switzerland, Lausanne, Switzerland
3 University Center for Primary Care and Public Health, University of Lausanne, Switzerland, Lausanne, Switzerland; Institute of Computer Science, University of Tartu, Tartu, Estonia
4 Computational Biology, Ontario Institute for Cancer Research, Toronto, ON, Canada
5 Department of Public Health Sciences, University of Chicago, Chicago, IL, USA
6 Singapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore
7 Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands
8 Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA; Department of Computer Science, Johns Hopkins University, Baltimore, MD, USA
9 Heart Center Leipzig, Universität Leipzig, Leipzig, Germany
10 Department of Genetics, University Medical Centre Groningen, Groningen, The Netherlands; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, UK; Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
11 Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
12 Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA
13 Department of Genetics, University Medical Centre Groningen, Groningen, The Netherlands
14 Department of Genetics, University Medical Centre Groningen, Groningen, The Netherlands; Genomics Coordination Center, University Medical Centre Groningen, Groningen, The Netherlands
15 Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia
16 Department of Computer Science, Johns Hopkins University, Baltimore, MD, USA
17 Exeter Medical School, University of Exeter, Exeter, UK
18 Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA; Department of Medicine, University of Washington, Seattle, WA, USA
19 School of Biological Sciences, Georgia Tech, Atlanta, GA, USA
20 MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK
21 Department of Psychiatry and Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands
22 Department of Clinical Physiology, Tampere University Hospital and Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
23 Centre for Life Course Health Research, University of Oulu, Oulu, Finland
24 Department of Computer Science, Johns Hopkins University, Baltimore, MD, USA; Genetics and Genomic Science Department, Icahn School of Medicine at Mount Sinai, New York, NY, USA
25 Institut für Medizinische Informatik, Statistik und Epidemiologie, LIFE – Leipzig Research Center for Civilization Diseases, Universität Leipzig, Leipzig, Germany
26 IFB Adiposity Diseases, Universität Leipzig, Leipzig, Germany
27 Interdisciplinary Center for Clinical Research, Faculty of Medicine, Universität Leipzig, Leipzig, Germany
28 Department of Clinical Chemistry, Fimlab Laboratories and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
29 Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia
30 Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany; Department of Medicine I, University Hospital Munich, Ludwig Maximilian’s University, München, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany
31 Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany
32 National Institute for Health and Welfare, University of Helsinki, Helsinki, Finland
33 Garvan Institute of Medical Research, Garvan-Weizmann Centre for Cellular Genomics, Sydney, Australia
34 Institute of Human Genetics, Helmholtz Zentrum München, Neuherberg, Germany; Institute of Human Genetics, Technical University Munich, Munich, Germany
35 Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA; Departments of Epidemiology, Medicine, and Health Services, University of Washington, Seattle, WA, USA; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA
36 Centre for Population Health Research, Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital and University of Turku, Turku, Finland
37 Statistical and Translational Genetics, University of Helsinki, Helsinki, Finland
38 DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany
39 Department of Internal Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands
40 Department of Medicine, Universität Leipzig, Leipzig, Germany
41 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
42 Center for Molecular and Biomolecular Informatics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center Nijmegen, Nijmegen, The Netherlands
43 Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany
44 Institute for Laboratory Medicine, LIFE – Leipzig Research Center for Civilization Diseases, Universität Leipzig, Leipzig, Germany
45 Department of Internal Medicine, Erasmus Medical Centre, Rotterdam, The Netherlands
46 Department of Neurology, University Medical Center Utrecht, Utrecht, The Netherlands
47 Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany
48 Department of Genetics, University Medical Centre Groningen, Groningen, The Netherlands; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia
49 Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia; Institute for Advanced Research, Wenzhou Medical University, Wenzhou, Zhejiang, China
50 Molecular Epidemiology Section, Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands
51 SURFsara, Amsterdam, The Netherlands
52 Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
53 Department of Epidemiology, ErasmusMC, Rotterdam, The Netherlands
54 Department of Genetic Epidemiology, ErasmusMC, Rotterdam, The Netherlands
55 University Center for Primary Care and Public Health, University of Lausanne, Switzerland, Lausanne, Switzerland
56 Medical Statistics Section, Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands
57 Sequence Analysis Support Core, Leiden University Medical Center, Leiden, The Netherlands
58 Department of Internal Medicine and School for Cardiovascular Diseases (CARIM), Maastricht University Medical Center, Maastricht, The Netherlands
59 Genomics Coordination Center, University Medical Centre Groningen, Groningen, The Netherlands
60 Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
61 Endocrine, Diabetes, and Metabolism Service, CHUV and University of Lausanne, Lausanne, Switzerland
62 Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland
; Rüeger, Sina 2
; Lepik, Kaido 3
; Agbessi, Mawussé 4 ; Ahsan, Habibul 5 ; Alves, Isabel 4 ; Andiappan, Anand 6 ; Wibowo Arindrarto 7 ; Awadalla, Philip 4 ; Battle, Alexis 8 ; Beutner, Frank 9 ; Bonder, Marc Jan 10 ; Boomsma, Dorret 11 ; Christiansen, Mark 12 ; Claringbould, Annique 13 ; Deelen, Patrick 14 ; Tõnu Esko 15 ; Marie-Julie Favé 16 ; Franke, Lude 13 ; Frayling, Timothy 17 ; Gharib, Sina A 18 ; Gibson, Gregory 19 ; Heijmans, Bastiaan T 7 ; Gibran Hemani 20 ; Jansen, Rick 21 ; Kähönen, Mika 22 ; Kalnapenkis, Anette 15 ; Silva Kasela 15 ; Kettunen, Johannes 23 ; Kim, Yungil 24 ; Kirsten, Holger 25 ; Kovacs, Peter 26 ; Krohn, Knut 27 ; Kronberg-Guzman, Jaanika 15 ; Kukushkina, Viktorija 15 ; Lee, Bernett 6 ; Lehtimäki, Terho 28 ; Loeffler, Markus 25 ; Marigorta, Urko M 19 ; Hailang Mei 7 ; Milani, Lili 15 ; Montgomery, Grant W 29 ; Müller-Nurasyid, Martina 30 ; Nauck, Matthias 31 ; Nivard, Michel 11 ; Penninx, Brenda 22 ; Perola, Markus 32 ; Pervjakova, Natalia 15 ; Pierce, Brandon L 5 ; Powell, Joseph 33 ; Prokisch, Holger 34 ; Psaty, Bruce M 35 ; Raitakari, Olli T 36 ; Ripatti, Samuli 37 ; Rotzschke, Olaf 6 ; Saha, Ashis 16 ; Scholz, Markus 25 ; Schramm, Katharina 38 ; Seppälä, Ilkka 28 ; Slagboom, Eline P 7 ; Stehouwer, Coen D A 39 ; Stumvoll, Michael 40 ; Sullivan, Patrick 41 ; Peter A C ‘t Hoen 42 ; Teumer, Alexander 43 ; Thiery, Joachim 44 ; Lin, Tong 5 ; Tönjes, Anke 40 ; Jenny van Dongen 11 ; Maarten van Iterson 7 ; Joyce van Meurs 45 ; Veldink, Jan H 46 ; Verlouw, Joost 45 ; Visscher, Peter M 29 ; Völker, Uwe 47 ; Võsa, Urmo 48 ; Harm-Jan Westra 13 ; Wijmenga, Cisca 13 ; Yaghootkar, Hanieh 17 ; Yang, Jian 49 ; Zeng, Biao 19 ; Zhang, Futao 29 ; Beekman, Marian 50 ; Boomsma, Dorret I 11 ; Bot, Jan 51 ; Deelen, Joris 50 ; Peter A C ’t Hoen 52 ; Hofman, Bert A 53 ; Hottenga, Jouke J 11 ; Isaacs, Aaron 54 ; P Mila Jhamai 55 ; Kielbasa, Szymon M 56 ; Lakenberg, Nico 50 ; Luijk, René 50 ; Mei, Hailiang 57 ; Moed, Matthijs 50 ; Nooren, Irene 51 ; Pool, René 11 ; Schalkwijk, Casper G 58 ; P Eline Slagboom 50 ; H Eka D Suchiman 50 ; Swertz, Morris A 59 ; Tigchelaar, Ettje F 13 ; Uitterlinden, André G 45 ; Leonard H van den Berg 51 ; Ruud van der Breggen 50 ; Carla J H van der Kallen 58 ; Freerk van Dijk 59 ; van Duijn, Cornelia M 54 ; Michiel van Galen 52 ; Marleen M J van Greevenbroek 58 ; Diana van Heemst 60 ; Jeroen van Rooij 45 ; Peter van’t Hof 57 ; van Zwet, Erik W 56 ; Vermaat, Martijn 52 ; Verbiest, Michael 45 ; Verkerk, Marijn 45 ; Zhernakova, Dasha V 13 ; Zhernakova, Sasha 13 ; Santoni, Federico A 61 ; Reymond, Alexandre 62 ; Kutalik, Zoltán 2 1 Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland; Swiss Institute of Bioinformatics, Lausanne, Switzerland
2 Swiss Institute of Bioinformatics, Lausanne, Switzerland; University Center for Primary Care and Public Health, University of Lausanne, Switzerland, Lausanne, Switzerland
3 University Center for Primary Care and Public Health, University of Lausanne, Switzerland, Lausanne, Switzerland; Institute of Computer Science, University of Tartu, Tartu, Estonia
4 Computational Biology, Ontario Institute for Cancer Research, Toronto, ON, Canada
5 Department of Public Health Sciences, University of Chicago, Chicago, IL, USA
6 Singapore Immunology Network, Agency for Science, Technology and Research, Singapore, Singapore
7 Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands
8 Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA; Department of Computer Science, Johns Hopkins University, Baltimore, MD, USA
9 Heart Center Leipzig, Universität Leipzig, Leipzig, Germany
10 Department of Genetics, University Medical Centre Groningen, Groningen, The Netherlands; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, UK; Genome Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany
11 Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
12 Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA
13 Department of Genetics, University Medical Centre Groningen, Groningen, The Netherlands
14 Department of Genetics, University Medical Centre Groningen, Groningen, The Netherlands; Genomics Coordination Center, University Medical Centre Groningen, Groningen, The Netherlands
15 Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia
16 Department of Computer Science, Johns Hopkins University, Baltimore, MD, USA
17 Exeter Medical School, University of Exeter, Exeter, UK
18 Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA; Department of Medicine, University of Washington, Seattle, WA, USA
19 School of Biological Sciences, Georgia Tech, Atlanta, GA, USA
20 MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK
21 Department of Psychiatry and Amsterdam Neuroscience, Amsterdam UMC, Vrije Universiteit, Amsterdam, The Netherlands
22 Department of Clinical Physiology, Tampere University Hospital and Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
23 Centre for Life Course Health Research, University of Oulu, Oulu, Finland
24 Department of Computer Science, Johns Hopkins University, Baltimore, MD, USA; Genetics and Genomic Science Department, Icahn School of Medicine at Mount Sinai, New York, NY, USA
25 Institut für Medizinische Informatik, Statistik und Epidemiologie, LIFE – Leipzig Research Center for Civilization Diseases, Universität Leipzig, Leipzig, Germany
26 IFB Adiposity Diseases, Universität Leipzig, Leipzig, Germany
27 Interdisciplinary Center for Clinical Research, Faculty of Medicine, Universität Leipzig, Leipzig, Germany
28 Department of Clinical Chemistry, Fimlab Laboratories and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland
29 Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia
30 Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany; Department of Medicine I, University Hospital Munich, Ludwig Maximilian’s University, München, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany
31 Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany
32 National Institute for Health and Welfare, University of Helsinki, Helsinki, Finland
33 Garvan Institute of Medical Research, Garvan-Weizmann Centre for Cellular Genomics, Sydney, Australia
34 Institute of Human Genetics, Helmholtz Zentrum München, Neuherberg, Germany; Institute of Human Genetics, Technical University Munich, Munich, Germany
35 Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA; Departments of Epidemiology, Medicine, and Health Services, University of Washington, Seattle, WA, USA; Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA
36 Centre for Population Health Research, Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital and University of Turku, Turku, Finland
37 Statistical and Translational Genetics, University of Helsinki, Helsinki, Finland
38 DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany
39 Department of Internal Medicine, Maastricht University Medical Centre, Maastricht, The Netherlands
40 Department of Medicine, Universität Leipzig, Leipzig, Germany
41 Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
42 Center for Molecular and Biomolecular Informatics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center Nijmegen, Nijmegen, The Netherlands
43 Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany
44 Institute for Laboratory Medicine, LIFE – Leipzig Research Center for Civilization Diseases, Universität Leipzig, Leipzig, Germany
45 Department of Internal Medicine, Erasmus Medical Centre, Rotterdam, The Netherlands
46 Department of Neurology, University Medical Center Utrecht, Utrecht, The Netherlands
47 Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany
48 Department of Genetics, University Medical Centre Groningen, Groningen, The Netherlands; Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia
49 Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia; Institute for Advanced Research, Wenzhou Medical University, Wenzhou, Zhejiang, China
50 Molecular Epidemiology Section, Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands
51 SURFsara, Amsterdam, The Netherlands
52 Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
53 Department of Epidemiology, ErasmusMC, Rotterdam, The Netherlands
54 Department of Genetic Epidemiology, ErasmusMC, Rotterdam, The Netherlands
55 University Center for Primary Care and Public Health, University of Lausanne, Switzerland, Lausanne, Switzerland
56 Medical Statistics Section, Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands
57 Sequence Analysis Support Core, Leiden University Medical Center, Leiden, The Netherlands
58 Department of Internal Medicine and School for Cardiovascular Diseases (CARIM), Maastricht University Medical Center, Maastricht, The Netherlands
59 Genomics Coordination Center, University Medical Centre Groningen, Groningen, The Netherlands
60 Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
61 Endocrine, Diabetes, and Metabolism Service, CHUV and University of Lausanne, Lausanne, Switzerland
62 Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland
Pages
1-12
Publication year
2019
Publication date
Jul 2019
e-ISSN
20411723
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2263286439
Copyright
© 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.