Details
Title
Metabolomics reveals a link between homocysteine and lipid metabolism and leukocyte telomere length: the ENGAGE consortium
Author
van der Spek, Ashley 1
; Broer, Linda 2 ; Draisma, Harmen H M 3 ; Pool, René 4
; Albrecht, Eva 5 ; Beekman, Marian 6
; Mangino, Massimo 7
; Raag, Mait 8 ; Nyholt, Dale R 9 ; Dharuri, Harish K 10 ; Codd, Veryan 11 ; Amin, Najaf 1 ; Eco J C de Geus 12 ; Deelen, Joris 13
; Demirkan, Ayse 14 ; Yet, Idil 15 ; Fischer, Krista 16 ; Haller, Toomas 17 ; Henders, Anjali K 18 ; Isaacs, Aaron 19
; Medland, Sarah E 20 ; Montgomery, Grant W 20 ; Mooijaart, Simon P 21 ; Strauch, Konstantin 22 ; H Eka D Suchiman 6
; Vaarhorst, Anika A M 6 ; Diana van Heemst 21 ; Wang-Sattler, Rui 23 ; Whitfield, John B 20 ; Willemsen, Gonneke 12 ; Wright, Margaret J 24 ; Martin, Nicholas G 20 ; Samani, Nilesh J 11 ; Metspalu, Andres 17 ; P Eline Slagboom 6 ; Spector, Tim D 25 ; Boomsma, Dorret I 4 ; van Duijn, Cornelia M 26 ; Gieger, Christian 5
1 Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
2 Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
3 Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands; Amsterdam Public Health research institute, Amsterdam University Medical Centers, Amsterdam, The Netherlands; Section of Genomics of Common Disease, Imperial College London, Burlington Danes Building Room E301, Du Cane Road, London, UK
4 Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands; Amsterdam Public Health research institute, Amsterdam University Medical Centers, Amsterdam, The Netherlands; BBMRI-NL: Infrastructure for the Application of Metabolomics Technology in Epidemiology (RP4), Utrecht, The Netherlands
5 Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany
6 Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands
7 Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK; NIHR Biomedical Research Centre at Guy’s and St Thomas’ Foundation Trust, London, UK
8 Institute of Family Medicine and Public Health, University of Tartu, Tartu, Estonia
9 School of Biomedical Sciences, Faculty of Health, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, Australia
10 Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
11 Department of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK
12 Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands; Amsterdam Public Health research institute, Amsterdam University Medical Centers, Amsterdam, The Netherlands
13 Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands; Max Planck Institute for Biology of Ageing, Cologne, Germany
14 Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
15 Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK; Department of Bioinformatics, Institute of Health Sciences, Hacettepe University, 06100, Ankara, Turkey
16 Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia; Institute of Mathematics and Statistics, University of Tartu, Tartu, Estonia
17 Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia
18 The Institute for Molecular Biosciences, The University of Queensland, Brisbane, Australia
19 CARIM School for Cardiovascular Diseases, Maastricht Centre for Systems Biology (MaCSBio), and Department of Biochemistry, Maastricht University, Maastricht, The Netherlands
20 QIMR Berghofer Medical Research Institute, Brisbane, Australia
21 Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
22 Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany; Chair of Genetic Epidemiology, IBE, Faculty of Medicine, LMU Munich, Germany
23 Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany
24 Queensland Brain Institute, The University of Queensland, Brisbane, Australia
25 Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK
26 Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands; Leiden Academic Centre for Drug Research, Leiden University, Leiden, Netherlands; Nuffield Department of Population Health, University of Oxford, Oxford, UK
; Broer, Linda 2 ; Draisma, Harmen H M 3 ; Pool, René 4
; Albrecht, Eva 5 ; Beekman, Marian 6
; Mangino, Massimo 7
; Raag, Mait 8 ; Nyholt, Dale R 9 ; Dharuri, Harish K 10 ; Codd, Veryan 11 ; Amin, Najaf 1 ; Eco J C de Geus 12 ; Deelen, Joris 13
; Demirkan, Ayse 14 ; Yet, Idil 15 ; Fischer, Krista 16 ; Haller, Toomas 17 ; Henders, Anjali K 18 ; Isaacs, Aaron 19
; Medland, Sarah E 20 ; Montgomery, Grant W 20 ; Mooijaart, Simon P 21 ; Strauch, Konstantin 22 ; H Eka D Suchiman 6
; Vaarhorst, Anika A M 6 ; Diana van Heemst 21 ; Wang-Sattler, Rui 23 ; Whitfield, John B 20 ; Willemsen, Gonneke 12 ; Wright, Margaret J 24 ; Martin, Nicholas G 20 ; Samani, Nilesh J 11 ; Metspalu, Andres 17 ; P Eline Slagboom 6 ; Spector, Tim D 25 ; Boomsma, Dorret I 4 ; van Duijn, Cornelia M 26 ; Gieger, Christian 5 1 Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
2 Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
3 Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands; Amsterdam Public Health research institute, Amsterdam University Medical Centers, Amsterdam, The Netherlands; Section of Genomics of Common Disease, Imperial College London, Burlington Danes Building Room E301, Du Cane Road, London, UK
4 Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands; Amsterdam Public Health research institute, Amsterdam University Medical Centers, Amsterdam, The Netherlands; BBMRI-NL: Infrastructure for the Application of Metabolomics Technology in Epidemiology (RP4), Utrecht, The Netherlands
5 Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany
6 Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands
7 Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK; NIHR Biomedical Research Centre at Guy’s and St Thomas’ Foundation Trust, London, UK
8 Institute of Family Medicine and Public Health, University of Tartu, Tartu, Estonia
9 School of Biomedical Sciences, Faculty of Health, Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, Australia
10 Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
11 Department of Cardiovascular Sciences, University of Leicester and NIHR Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, UK
12 Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands; Amsterdam Public Health research institute, Amsterdam University Medical Centers, Amsterdam, The Netherlands
13 Molecular Epidemiology, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands; Max Planck Institute for Biology of Ageing, Cologne, Germany
14 Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands; Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
15 Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK; Department of Bioinformatics, Institute of Health Sciences, Hacettepe University, 06100, Ankara, Turkey
16 Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia; Institute of Mathematics and Statistics, University of Tartu, Tartu, Estonia
17 Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia
18 The Institute for Molecular Biosciences, The University of Queensland, Brisbane, Australia
19 CARIM School for Cardiovascular Diseases, Maastricht Centre for Systems Biology (MaCSBio), and Department of Biochemistry, Maastricht University, Maastricht, The Netherlands
20 QIMR Berghofer Medical Research Institute, Brisbane, Australia
21 Department of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands
22 Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany; Chair of Genetic Epidemiology, IBE, Faculty of Medicine, LMU Munich, Germany
23 Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany
24 Queensland Brain Institute, The University of Queensland, Brisbane, Australia
25 Department of Twin Research and Genetic Epidemiology, King’s College London, London, UK
26 Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands; Leiden Academic Centre for Drug Research, Leiden University, Leiden, Netherlands; Nuffield Department of Population Health, University of Oxford, Oxford, UK
Pages
1-12
Publication year
2019
Publication date
Aug 2019
e-ISSN
20452322
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2272204844
Copyright
© 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.