Abstract

Cancer is the deadliest human disease and the development of new diagnosis methods is important to increase the chances of a cure. In this work it was developed a new method, named here for the first time as cerumenogram, using cerumen (earwax) as a new biomatrix for diagnosis. Earwax samples collected from cancer patients (cancer group) and cancer-free patients (control group) were analyzed by Headspace/Gas Chromatography-Mass Spectrometry (HS/GC-MS), following with multivariate analysis steps to process the raw data generated. In total, 158 volatile organic metabolites (VOMs) were identified in the cerumen samples. The 27 selected as potential VOMs biomarkers for cancer provided 100% discrimination between the cancer and control groups. This new test can thus be routinely employed for cancer diagnoses that is non-invasive, fast, cheap, and highly accurate.

Details

Title
Cerumenogram: a new frontier in cancer diagnosis in humans
Author
João Marcos Gonçalves Barbosa 1   VIAFID ORCID Logo  ; Pereira, Naiara Zedes 1 ; Lurian Caetano David 1   VIAFID ORCID Logo  ; de Oliveira, Camilla Gabriela 2   VIAFID ORCID Logo  ; Marina Ferraz Gontijo Soares 2 ; Melissa Ameloti Gomes Avelino 2 ; Anselmo Elcana de Oliveira 3 ; Shokry, Engy 1   VIAFID ORCID Logo  ; Nelson Roberto Antoniosi Filho 4   VIAFID ORCID Logo 

1  Laboratory of Extraction and Separation Methods (LAMES), Institute of Chemistry, Federal University of Goiás (UFG), Campus II - Samambaia, Goiânia, GO, Brazil 
2  Clinical Hospital, Federal University of Goiás (UFG), Campus I – Colemar Natal e Silva, Goiânia, GO, Brazil 
3  Laboratory of Theoretical and Computational Chemistry (LQTC), Institute of Chemistry, Federal University of Goiás (UFG), Campus II - Samambaia, Goiânia, GO, Brazil 
4  Laboratory of Extraction and Separation Methods (LAMES), Institute of Chemistry, Federal University of Goiás (UFG), Campus II - Samambaia, Goiânia, GO, Brazil; Laboratory of Extraction and Separation Methods (LAMES), Institute of Chemistry, Federal University of Goiás (UFG), Campus II - Samambaia, Goiânia, GO, Brazil 
Pages
1-9
Publication year
2019
Publication date
Aug 2019
Publisher
Nature Publishing Group
e-ISSN
20452322
Source type
Scholarly Journal
Language of publication
English
DOI
https://doi.org/10.1038/s41598-019-48121-4
ProQuest document ID
2272720177
Copyright
© 2019. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.