Evaluation of the antidepressant activity of Tricholepis glaberrima bark alone and in combination with Mimosa pudica root extract

Abstract

Materials and Methods: Ethanolic extract of T glaberrima bark and M. pudica root extracts was prepared followed by analysis of phytochemical constituents was determined using appropriate biochemical method, acute toxicity studies also performed, and the biological investigation of both plants extracts was conducted through pharmacological screening models (forced swimming test and tail suspension test) in Swiss albino mice. Various pharmacological agents such as antidepressants including selective serotonin reuptake inhibitors, SNRIs, and tricyclic antidepressant therapies, increase the neurogenesis and synaptic connectivity in the cortical area such as hippocampus. Effect of the Acute Treatment of ETGB Alone and in Combination of EMPR on Antidepressant Models in Mice The result represented in Figures 1 and 2 showed that drugs given 14 constitutive days by oral route of administration reduced the time of immobility time in FST and TST models, a behavioral profile characteristic of antidepressant-like effect. [14] ETGB and EMPR extracts are a rich dietary supplement of flavonoid, alkaloids, glycosides, carbohydrates, proteins, saponins, steroids, and phenolic compounds might responsible for to net enhancement of depression among the patients CONCLUSION Ethanolic extract of T glaberrima extracts shown significant antidepressant activity alone and in combination with M. pudica roots highly efficacious than alone treated groups and comparable to reference standard drug imipramine.