It appears you don't have support to open PDFs in this web browser. To view this file, Open with your PDF reader
Abstract
Phenotypic variation of quantitative traits is orchestrated by a complex interplay between the environment (e.g. diet) and genetics. However, the impact of gene-environment interactions on phenotypic traits mostly remains elusive. To address this, we feed 1154 mice of an autoimmunity-prone intercross line (AIL) three different diets. We find that diet substantially contributes to the variability of complex traits and unmasks additional genetic susceptibility quantitative trait loci (QTL). By performing whole-genome sequencing of the AIL founder strains, we resolve these QTLs to few or single candidate genes. To address whether diet can also modulate genetic predisposition towards a given trait, we set NZM2410/J mice on similar dietary regimens as AIL mice. Our data suggest that diet modifies genetic susceptibility to lupus and shifts intestinal bacterial and fungal community composition, which precedes clinical disease manifestation. Collectively, our study underlines the importance of including environmental factors in genetic association studies.
You have requested "on-the-fly" machine translation of selected content from our databases. This functionality is provided solely for your convenience and is in no way intended to replace human translation. Show full disclaimer
Neither ProQuest nor its licensors make any representations or warranties with respect to the translations. The translations are automatically generated "AS IS" and "AS AVAILABLE" and are not retained in our systems. PROQUEST AND ITS LICENSORS SPECIFICALLY DISCLAIM ANY AND ALL EXPRESS OR IMPLIED WARRANTIES, INCLUDING WITHOUT LIMITATION, ANY WARRANTIES FOR AVAILABILITY, ACCURACY, TIMELINESS, COMPLETENESS, NON-INFRINGMENT, MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. Your use of the translations is subject to all use restrictions contained in your Electronic Products License Agreement and by using the translation functionality you agree to forgo any and all claims against ProQuest or its licensors for your use of the translation functionality and any output derived there from. Hide full disclaimer
Details












1 Lübeck Institute of Experimental Dermatology and Center for Research on Inflammation of the Skin, University of Lübeck, Lübeck, Germany; Department of Dermatology and Center for Research on Inflammation of the Skin, University of Lübeck, Lübeck, Germany
2 Lübeck Institute of Experimental Dermatology and Center for Research on Inflammation of the Skin, University of Lübeck, Lübeck, Germany
3 Department of Dermatology and Center for Research on Inflammation of the Skin, University of Lübeck, Lübeck, Germany
4 Lübeck Institute of Experimental Dermatology and Center for Research on Inflammation of the Skin, University of Lübeck, Lübeck, Germany; Department of Dermatology, Kurume University School of Medicine, Kurume, Fukuoka, Japan
5 Laboratories of Immunology and Antibody Glycan Analysis, Institute for Nutritional Medicine, University of Lübeck and University Medical Center Schleswig-Holstein, Lübeck, Germany
6 Max Planck Institute for Evolutionary Biology, Plön, Germany; Institute for Experimental Medicine, Kiel University, Kiel, Germany
7 Max Planck Institute for Evolutionary Biology, Plön, Germany
8 Institute of Nutritional Medicine, Molecular Gastroenterology, University of Lübeck, Ratzeburger Allee 160, Lübeck, Germany
9 Lübeck Institute of Experimental Dermatology and Center for Research on Inflammation of the Skin, University of Lübeck, Lübeck, Germany; Department of Urology, University Medical Center Goettingen, Goettingen, Germany
10 Institute for Systemic Inflammation Research, University of Lübeck, Lübeck, Germany
11 Department of Dermatology, Venereology and Allergology, Goethe University, Frankfurt am Main, Germany
12 Divison of Dermatology and Venereology, Geneva University Hospitals, and Department of Pathology and Immunology, University of Geneva, Genève, Switzerland
13 Center for Excellence in Vascular Biology, Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA
14 Center for Excellence in Vascular Biology, Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA; Department of Nephrology and Endocrinology, University of Tokyo, Tokyo, Japan
15 Institute for Biostatistics and Informatics in Medicine and Ageing Research, Rostock University of Rostock, Germany