Abstract
The ability of adipose-derived stromal/stem cells (ASCs) to facilitate long-term allograft survival was investigated. ASC and bone marrow cell (BMC) coinfusion with minimal conditioning led to stable lymphoid and myeloid macrochimerism, deletion of alloreactive T cells, expansion of regulatory T cells, and long-term allograft survival (>200 days). Translational advanced vascular composite allotransplants with ASCs and low-dose donor BMCs in nonhuman primates can be developed to enhance functional outcomes and eliminate long-term immunosuppression.
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1 Regenerative Medicine Department, Operational and Undersea Medicine Directorate, Naval Medical Research Center, Silver Spring, Maryland, USA; Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
2 Regenerative Medicine Department, Operational and Undersea Medicine Directorate, Naval Medical Research Center, Silver Spring, Maryland, USA
3 Department of Medicine and Surgery Center for Stem Cell Research & Regenerative Medicine, Tulane University School of Medicine, New Orleans, Louisiana, USA; LaCell, LLC, New Orleans, Louisiana, USA