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Abstract
A rapid and robust method to generate therapeutic resident lung progenitors from adult lung tissues is reported. Outgrowth cells from healthy lung explants were self-aggregated into three-dimensional lung spheroids. Lung spheroid cells inhibited apoptosis, fibrosis, and infiltration but promoted angiogenesis and outperformed adipose-derived mesenchymal stem cells, suggesting that lung spheroids and lung spheroid cells from healthy lung tissues are excellent sources of regenerative lung cells for therapeutic lung regeneration.
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1 Department of Molecular Biomedical Sciences and Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA; Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, and North Carolina State University, Raleigh, North Carolina, USA
2 Department of Molecular Biomedical Sciences and Center for Comparative Medicine and Translational Research, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina, USA
3 Department of Biology, North Carolina State University, Raleigh, North Carolina, USA
4 Division of Cardiothoracic Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
5 Division of Pulmonary Diseases and Critical Care Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA