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Abstract
Excessive scar formation caused by myofibroblast aggregations is of great clinical importance during skin wound healing. Umbilical cord-derived mesenchymal stem cells (uMSCs) reduced scar formation and myofibroblast accumulation in a skin-defect mouse model. A novel role of exosomal microRNAs in uMSC-mediated therapy was demonstrated, suggesting that the clinical application of uMSC-derived exosomes might represent a strategy to prevent scar formation during wound healing.
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Details
1 Department of Plastic and Reconstruction, Shanghai Changhai Hospital Affiliated to Second Military Medical University, Shanghai, People's Republic of China
2 Department of Spinal Surgery, Changzheng Hospital Affiliated to Second Military Medical University, Shanghai, People's Republic of China
3 Department of Emergency and Trauma, Shanghai Changhai Hospital Affiliated to Second Military Medical University, Shanghai, People's Republic of China
4 Department of Microbiology, Shanghai Key Laboratory of Medical Biodefense, Second Military Medical University, Shanghai, People's Republic of China
5 Research Center of Developmental Biology, Second Military Medical University, Shanghai, People's Republic of China
6 Research Center of Developmental Biology, Second Military Medical University, Shanghai, People's Republic of China; Translational Medicine Center, Second Military Medical University, Shanghai, People's Republic of China