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© 2016. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.

Abstract

Background

Huntington's disease (HD) causes progressive atrophy to the striatum, a critical node in frontostriatal circuitry. Maintenance of motor function is dependent on functional connectivity of these premotor, motor, and dorsolateral frontostriatal circuits, and structural integrity of the striatum itself. We aimed to investigate whether size and shape of the striatum as a measure of frontostriatal circuit structural integrity was correlated with functional frontostriatal electrophysiological neural premotor processing (contingent negative variation, CNV), to better understand motoric structure–function relationships in early HD.

Methods

Magnetic resonance imaging (MRI) scans and electrophysiological (EEG) measures of premotor processing were obtained from a combined HD group (12 presymptomatic, 7 symptomatic). Manual segmentation of caudate and putamen was conducted with subsequent shape analysis. Separate correlational analyses (volume and shape) included covariates of age, gender, intracranial volume, and time between EEG and MRI.

Results

Right caudate volume correlated with early CNV latency over frontocentral regions and late CNV frontally, whereas right caudate shape correlated with early CNV latency centrally. Left caudate volume correlated with early CNV latency over centroparietal regions and late CNV frontally. Right and left putamen volumes correlated with early CNV latency frontally, and right and left putamen shape/volume correlated with parietal CNV slope.

Conclusions

Timing (latency) and pattern (slope) of frontostriatal circuit‐mediated premotor functional activation across scalp regions were correlated with abnormalities in structural integrity of the key frontostriatal circuit component, the striatum (size and shape). This was accompanied by normal reaction times, suggesting it may be undetected in regular tasks due to preserved motor “performance.” Such differences in functional activation may reflect atrophy‐based frontostriatal circuitry despecialization and/or compensatory recruitment of additional brain regions.

Details

Title
Striatal morphology correlates with frontostriatal electrophysiological motor processing in Huntington's disease: an IMAGE‐HD study
Author
Turner, Lauren M 1 ; Jakabek, David 2 ; Wilkes, Fiona A 3 ; Croft, Rodney J 4 ; Churchyard, Andrew 5 ; Walterfang, Mark 6 ; Velakoulis, Dennis 6 ; Looi, Jeffrey C L 7 ; Nellie Georgiou‐Karistianis 8 ; Apthorp, Deborah 9 

 Research School of Psychology, College of Medicine, Biology, & Environment, Australian National University, Canberra, Australian Capital Territory, Australia 
 Graduate School of Medicine, University of Wollongong, Wollongong, New South Wales, Australia 
 Academic Unit of Psychiatry and Addiction Medicine, Australian National University Medical School, Canberra Hospital, Canberra, Australian Capital Territory, Australia 
 School of Psychology & Illawarra Health & Medical Research Institute, University of Wollongong, Wollongong, New South Wales, Australia 
 School of Psychological Sciences, Faculty of Medicine, Nursing and Health Sciences, Monash University, Monash, Victoria, Australia; Calvary Health Care Bethlehem Hospital, Caulfield, Victoria, Australia 
 Neuropsychiatry Unit, Royal Melbourne Hospital, and Melbourne Neuropsychiatry Centre, University of Melbourne, Melbourne, Victoria, Australia 
 Academic Unit of Psychiatry and Addiction Medicine, Australian National University Medical School, Canberra Hospital, Canberra, Australian Capital Territory, Australia; Neuropsychiatry Unit, Royal Melbourne Hospital, and Melbourne Neuropsychiatry Centre, University of Melbourne, Melbourne, Victoria, Australia 
 School of Psychological Sciences, Faculty of Medicine, Nursing and Health Sciences, Monash University, Monash, Victoria, Australia 
 Research School of Psychology, College of Medicine, Biology, & Environment, Australian National University, Canberra, Australian Capital Territory, Australia; Graduate School of Medicine, University of Wollongong, Wollongong, New South Wales, Australia 
Section
Original Research
Publication year
2016
Publication date
Dec 2016
Publisher
John Wiley & Sons, Inc.
e-ISSN
21623279
Source type
Scholarly Journal
Language of publication
English
ProQuest document ID
2290239432
Copyright
© 2016. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.