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Abstract
This study characterizes the cellular niche required for the expansion of human spermatogonial stem cells (SSCs), provides strong evidence supporting specific extracellular markers that define a testicular cell population highly enriched for human SSCs, and characterizes a novel testicular multipotent stromal cell population essential for SSC expansion. The results of this study are very important to understanding how human SSCs can be grown and expanded successfully in vitro for future therapeutic applications.
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Details
1 Department of Urology, University of California, San Francisco, San Francisco, California, USA; Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, San Francisco, California, USA
2 Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, San Francisco, California, USA
3 Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco, San Francisco, California, USA; Helen Schneider Hospital for Women, Rabin Medical Center, Petah-Tiqva, Israel
4 Department of Urology, University of California, San Francisco, San Francisco, California, USA
5 Department of Obstetrics and Gynecology, Albert Einstein University, Bronx, New York, USA