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Abstract
In vivo integration of smooth muscle progenitor cells (pSMCs) derived from human pluripotent stem cells was examined. pSMCs were derived from a human embryonic stem cell line and two induced pluripotent stem cell lines. The data suggest that hPSC-derived pSMCs facilitate restoration of urethral sphincter function by direct smooth muscle cell regeneration and by inducing native tissue elastin/collagen III remodeling.
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1 Department of Obstetrics/Gynecology, Stanford University School of Medicine, Stanford, California, USA; Department of Obstetrics/Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, People’s Republic of China
2 Department of Obstetrics/Gynecology, Stanford University School of Medicine, Stanford, California, USA
3 Department of Obstetrics/Gynecology, Stanford University School of Medicine, Stanford, California, USA; Department of Obstetrics/Gynecology, NanFang Hospital, Southern Medical University, Guangzhou, Guangdong, People’s Republic of China
4 Department of Obstetrics/Gynecology, Stanford University School of Medicine, Stanford, California, USA; Institute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, California, USA
5 Department of Biomedical Engineering, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio, USA
6 Department of Biomedical Engineering, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio, USA; Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio, USA
7 Department of Cell Biology and Neuroscience, Montana State University, Bozeman, Montana, USA; Department of Chemistry and Biochemistry, Montana State University, Bozeman, Montana, USA