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Abstract
Adult dental pulp cells (DPCs) isolated from human third molars have the capability to differentiate into keratocytes. After inducing differentiation in vitro, DPCs expressed molecules characteristic of keratocytes, keratocan, and keratan sulfate proteoglycans at the gene and protein levels. DPCs maintain the keratocyte phenotype after in vivo transplantation, demonstrating a potential for clinical application in cellular or tissue engineering therapies for corneal stromal blindness.
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Details
1 Departments of Ophthalmology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
2 Departments of Ophthalmology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Departments of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
3 Departments of Ophthalmology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA; Departments of McGowan Institute of Regenerative Medicine, Pittsburgh, Pennsylvania, USA