Synthesis and Evaluation of Cytotoxicity Effect of New Ligand (LBe) and it's Complexes on a Cervical Cancer

Introduction

Indole ring is an aromatic heterocyclic compound.¹ A heterocyclic compound is one which possesses a cyclic structure with at least two various kinds of hetro atoms in the ring. Oxygen, nitrogenand sulfur are the most widespread hetrocyclic compounds are very vastly distributed in nature and are essential to life in different ways.² and³ In general, Schiff bases form through the reaction of a primary amine and ketone or aldehyde with removal of water molecule in convenient solvent.^4-6 Schiff bases have been known by various names such as azomethines, imines, and anils. Broadly, the Schiff bases that have been derived from aldehydes are named aldimine and from ketones are ketamine.⁷ and⁸In Schiff base azomethane nitrogen and other donor atoms like oxygen play a major role in coordination chemistry.⁹ Schiff bases are beneficial chelates because of their ease of preparation, structural varieties, assorted densities and subtle steric and electronic control on their framework.¹⁰ In industry, Schiff bases were used as corrosion inhibitors, rubber accelerators, and antioxidants, also used as plasticizers, and stabilizers for polymers, polymerization, initiators, antioxidants… etc.¹¹ and.¹² The transition metal one of the more interesting aspects to form coordination compounds.¹³ The coordination compound are of huge interest, because metal ions found in the active sites of a large number of metalloproteins such as, hemocyanin, and in metalloenzymes like in tyrosinase, ureases, lactase and ascorbateoxidase. These proteins are contributory in the various biological processes such as biological electron-transfer reaction, oxygen atom insertion into substrates, dioxygen reduction to hydrogen peroxide or water and hydrolytic reactions.¹⁴ Study of coordination chemistry of transition metal ions with unlike types of ligands has been enhanced by the current evolutions in the fields of medicine and bioinorganic chemistry.¹⁵ Through the years, Schiff bases have played a particular role as chelating ligands in coordination chemistry, due to their stabilization under a variety of oxidative and reductive conditions, and to the actuality that imine ligands are borderline between soft and hard Lewis bases.¹⁶ This research include synthesis and characterization of LBe compound and used as ligand to synthesize a new complexes by its reaction with different salts of metal chlorides in a molar ratio 1:1 and 1:2...